Chemical composition by HPLC-ESI-QTOF-MS/MS: Estrogenic and antioxidant effects of Mangifera indica L. cv. "Kent" leave extracts on ovariectomized rats

• Autores: Benites, J, Asuncion-Alvarez, HD, Ybanez-Julca, RO, Ganoza-Yupanqui, ML, Jacinto-Fernandez, JJ, Reyes-De la Vega, JB, Zavaleta-Cruz, HJ, Pinedo-Alcantara, AN, Layado-Fonseca, CM, Medina-Mejia, CA, Catalan, M, Morales, B, de Albuquerque, RDDG, Rocha, L, Martinez, JL
• Formato: artículo
• Fecha de Publicación: 2019
• Institución: Consejo Nacional de Ciencia Tecnología e Innovación
• Repositorio: CONCYTEC-Institucional
• Lenguaje: inglés
• OAI Identifier: oai:repositorio.concytec.gob.pe:20.500.12390/1037
• Enlace del recurso: https://hdl.handle.net/20.500.12390/1037; https://doi.org/10.37360/blacpma.19.18.3.21
• Nivel de acceso: acceso abierto
• Materia: Fitoquímica; Bioquímica; https://purl.org/pe-repo/ocde/ford#1.06.03

The chemical composition of Mangifera indicaL. cv. "Kent" leaves was determined by HPLC-ESI-QTOF-MS/MS. Polyphenolic compounds characterized as benzophenone derivatives were the main components found in extracts and xanthones. The estrogenic and antioxidant effects of aqueous extracts from Mangifera indica L. cv. "Kent" leaves on ovariectomized rats were determined by uterotrophic assay and malondialdehyde (MDA) levels in erythrocytes, bone, liver, and stomach. We conclude that the polyphenolic compounds from extracts act as exogenous antioxidant agents against oxidative damage in ovariectomized rats.