Doseresponse effect of black maca (Lepidium meyenii) in mice with memory impairment induced by ethanol

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The present study was supported by a grant obtained from Peruvian National Council of Sciences, Technology and Innovation (CONCYTEC) through the grant PROCOM 2008. All authors participated in the experimental design and development of the study. Also, the authors report no conflicts of interest. The...

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Detalles Bibliográficos
Autores: Rubio J., Yucra S., Gasco M., Gonzales G.F.
Formato: revisión
Fecha de Publicación:2011
Institución:Consejo Nacional de Ciencia Tecnología e Innovación
Repositorio:CONCYTEC-Institucional
Lenguaje:inglés
OAI Identifier:oai:repositorio.concytec.gob.pe:20.500.12390/686
Enlace del recurso:https://hdl.handle.net/20.500.12390/686
https://doi.org/10.3109/15376516.2011.583294
Nivel de acceso:acceso abierto
Materia:pyrogallol
ascorbic acid
Lepidium meyenii extract
polyphenol
alcohol
plant extract
animal experiment
controlled study
dose response
drug effect
locomotion
male
memory disorder
https://purl.org/pe-repo/ocde/ford#3.01.07
id CONC_e35755c0651db7fb37fbff1c97334b68
oai_identifier_str oai:repositorio.concytec.gob.pe:20.500.12390/686
network_acronym_str CONC
network_name_str CONCYTEC-Institucional
repository_id_str 4689
dc.title.none.fl_str_mv Doseresponse effect of black maca (Lepidium meyenii) in mice with memory impairment induced by ethanol
title Doseresponse effect of black maca (Lepidium meyenii) in mice with memory impairment induced by ethanol
spellingShingle Doseresponse effect of black maca (Lepidium meyenii) in mice with memory impairment induced by ethanol
Rubio J.
pyrogallol
ascorbic acid
Lepidium meyenii extract
polyphenol
alcohol
plant extract
animal experiment
controlled study
dose response
drug effect
locomotion
male
memory disorder
https://purl.org/pe-repo/ocde/ford#3.01.07
title_short Doseresponse effect of black maca (Lepidium meyenii) in mice with memory impairment induced by ethanol
title_full Doseresponse effect of black maca (Lepidium meyenii) in mice with memory impairment induced by ethanol
title_fullStr Doseresponse effect of black maca (Lepidium meyenii) in mice with memory impairment induced by ethanol
title_full_unstemmed Doseresponse effect of black maca (Lepidium meyenii) in mice with memory impairment induced by ethanol
title_sort Doseresponse effect of black maca (Lepidium meyenii) in mice with memory impairment induced by ethanol
author Rubio J.
author_facet Rubio J.
Yucra S.
Gasco M.
Gonzales G.F.
author_role author
author2 Yucra S.
Gasco M.
Gonzales G.F.
author2_role author
author
author
dc.contributor.author.fl_str_mv Rubio J.
Yucra S.
Gasco M.
Gonzales G.F.
dc.subject.none.fl_str_mv pyrogallol
topic pyrogallol
ascorbic acid
Lepidium meyenii extract
polyphenol
alcohol
plant extract
animal experiment
controlled study
dose response
drug effect
locomotion
male
memory disorder
https://purl.org/pe-repo/ocde/ford#3.01.07
dc.subject.es_PE.fl_str_mv ascorbic acid
Lepidium meyenii extract
polyphenol
alcohol
plant extract
animal experiment
controlled study
dose response
drug effect
locomotion
male
memory disorder
dc.subject.ocde.none.fl_str_mv https://purl.org/pe-repo/ocde/ford#3.01.07
description The present study was supported by a grant obtained from Peruvian National Council of Sciences, Technology and Innovation (CONCYTEC) through the grant PROCOM 2008. All authors participated in the experimental design and development of the study. Also, the authors report no conflicts of interest. The study was performed in 2008. Since 2009, Dr Gustavo F. Gonzales is in charged of CAYENATUR EIRL an enterprise that develops products based on Maca.
publishDate 2011
dc.date.accessioned.none.fl_str_mv 2024-05-30T23:13:38Z
dc.date.available.none.fl_str_mv 2024-05-30T23:13:38Z
dc.date.issued.fl_str_mv 2011
dc.type.none.fl_str_mv info:eu-repo/semantics/review
format review
dc.identifier.uri.none.fl_str_mv https://hdl.handle.net/20.500.12390/686
dc.identifier.doi.none.fl_str_mv https://doi.org/10.3109/15376516.2011.583294
dc.identifier.scopus.none.fl_str_mv 2-s2.0-80053264500
url https://hdl.handle.net/20.500.12390/686
https://doi.org/10.3109/15376516.2011.583294
identifier_str_mv 2-s2.0-80053264500
dc.language.iso.none.fl_str_mv eng
language eng
dc.relation.ispartof.none.fl_str_mv Toxicology Mechanisms and Methods
dc.rights.none.fl_str_mv info:eu-repo/semantics/openAccess
eu_rights_str_mv openAccess
dc.publisher.none.fl_str_mv Elsevier
publisher.none.fl_str_mv Elsevier
dc.source.none.fl_str_mv reponame:CONCYTEC-Institucional
instname:Consejo Nacional de Ciencia Tecnología e Innovación
instacron:CONCYTEC
instname_str Consejo Nacional de Ciencia Tecnología e Innovación
instacron_str CONCYTEC
institution CONCYTEC
reponame_str CONCYTEC-Institucional
collection CONCYTEC-Institucional
repository.name.fl_str_mv Repositorio Institucional CONCYTEC
repository.mail.fl_str_mv repositorio@concytec.gob.pe
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spelling Publicationrp01560600rp00125500rp00573500rp00575500Rubio J.Yucra S.Gasco M.Gonzales G.F.2024-05-30T23:13:38Z2024-05-30T23:13:38Z2011https://hdl.handle.net/20.500.12390/686https://doi.org/10.3109/15376516.2011.5832942-s2.0-80053264500The present study was supported by a grant obtained from Peruvian National Council of Sciences, Technology and Innovation (CONCYTEC) through the grant PROCOM 2008. All authors participated in the experimental design and development of the study. Also, the authors report no conflicts of interest. The study was performed in 2008. Since 2009, Dr Gustavo F. Gonzales is in charged of CAYENATUR EIRL an enterprise that develops products based on Maca.Previous studies have shown that black variety of maca has beneficial effects on learning and memory in experimental animal models. The present study aimed to determine whether the hydroalcoholic extract of black maca (BM) showed a dose–response effect in mice treated with ethanol 20% (EtOH) as a model of memory impairment. Mice were divided in the following groups: control, EtOH, ascorbic acid (AA) and 0.125, 0.25, 0.50 and 1.00 g/kg of BM plus EtOH. All treatments were orally administered for 28 days. Open field test was performed to determine locomotor activity and water Morris maze was done to determine spatial memory. Also, total polyphenol content in the hydroalcoholic extract of BM was determined (0.65 g pyrogallol/100 g). Mice treated with EtOH took more time to find the hidden platform than control during escape acquisition trials; meanwhile, AA and BM reversed the effect of EtOH. In addition, AA and BM ameliorated the deleterious effect of EtOH during the probe trial. Correlation analyses showed that the effect of BM a dose-dependent behavior. Finally, BM improved experimental memory impairment induced by ethanol in a dose–response manner due, in part, to its content of polyphenolic compounds.Consejo Nacional de Ciencia, Tecnología e Innovación Tecnológica - ConcytecengElsevierToxicology Mechanisms and Methodsinfo:eu-repo/semantics/openAccesspyrogallolascorbic acid-1Lepidium meyenii extract-1polyphenol-1alcohol-1plant extract-1animal experiment-1controlled study-1dose response-1drug effect-1locomotion-1male-1memory disorder-1https://purl.org/pe-repo/ocde/ford#3.01.07-1Doseresponse effect of black maca (Lepidium meyenii) in mice with memory impairment induced by ethanolinfo:eu-repo/semantics/reviewreponame:CONCYTEC-Institucionalinstname:Consejo Nacional de Ciencia Tecnología e Innovacióninstacron:CONCYTEC20.500.12390/686oai:repositorio.concytec.gob.pe:20.500.12390/6862024-05-30 15:58:33.718http://purl.org/coar/access_right/c_14cbinfo:eu-repo/semantics/closedAccessmetadata only accesshttps://repositorio.concytec.gob.peRepositorio Institucional CONCYTECrepositorio@concytec.gob.pe#PLACEHOLDER_PARENT_METADATA_VALUE##PLACEHOLDER_PARENT_METADATA_VALUE##PLACEHOLDER_PARENT_METADATA_VALUE##PLACEHOLDER_PARENT_METADATA_VALUE#<Publication xmlns="https://www.openaire.eu/cerif-profile/1.1/" id="0c61c72a-a0f7-4893-98df-132f15f7e002"> <Type xmlns="https://www.openaire.eu/cerif-profile/vocab/COAR_Publication_Types">http://purl.org/coar/resource_type/c_1843</Type> <Language>eng</Language> <Title>Doseresponse effect of black maca (Lepidium meyenii) in mice with memory impairment induced by ethanol</Title> <PublishedIn> <Publication> <Title>Toxicology Mechanisms and Methods</Title> </Publication> </PublishedIn> <PublicationDate>2011</PublicationDate> <DOI>https://doi.org/10.3109/15376516.2011.583294</DOI> <SCP-Number>2-s2.0-80053264500</SCP-Number> <Authors> <Author> <DisplayName>Rubio J.</DisplayName> <Person id="rp01560" /> <Affiliation> <OrgUnit> </OrgUnit> </Affiliation> </Author> <Author> <DisplayName>Yucra S.</DisplayName> <Person id="rp00125" /> <Affiliation> <OrgUnit> </OrgUnit> </Affiliation> </Author> <Author> <DisplayName>Gasco M.</DisplayName> <Person id="rp00573" /> <Affiliation> <OrgUnit> </OrgUnit> </Affiliation> </Author> <Author> <DisplayName>Gonzales G.F.</DisplayName> <Person id="rp00575" /> <Affiliation> <OrgUnit> </OrgUnit> </Affiliation> </Author> </Authors> <Editors> </Editors> <Publishers> <Publisher> <DisplayName>Elsevier</DisplayName> <OrgUnit /> </Publisher> </Publishers> <Keyword>pyrogallol</Keyword> <Keyword>ascorbic acid</Keyword> <Keyword>Lepidium meyenii extract</Keyword> <Keyword>polyphenol</Keyword> <Keyword>alcohol</Keyword> <Keyword>plant extract</Keyword> <Keyword>animal experiment</Keyword> <Keyword>controlled study</Keyword> <Keyword>dose response</Keyword> <Keyword>drug effect</Keyword> <Keyword>locomotion</Keyword> <Keyword>male</Keyword> <Keyword>memory disorder</Keyword> <Abstract>Previous studies have shown that black variety of maca has beneficial effects on learning and memory in experimental animal models. The present study aimed to determine whether the hydroalcoholic extract of black maca (BM) showed a dose–response effect in mice treated with ethanol 20% (EtOH) as a model of memory impairment. Mice were divided in the following groups: control, EtOH, ascorbic acid (AA) and 0.125, 0.25, 0.50 and 1.00 g/kg of BM plus EtOH. All treatments were orally administered for 28 days. Open field test was performed to determine locomotor activity and water Morris maze was done to determine spatial memory. Also, total polyphenol content in the hydroalcoholic extract of BM was determined (0.65 g pyrogallol/100 g). Mice treated with EtOH took more time to find the hidden platform than control during escape acquisition trials; meanwhile, AA and BM reversed the effect of EtOH. In addition, AA and BM ameliorated the deleterious effect of EtOH during the probe trial. Correlation analyses showed that the effect of BM a dose-dependent behavior. Finally, BM improved experimental memory impairment induced by ethanol in a dose–response manner due, in part, to its content of polyphenolic compounds.</Abstract> <Access xmlns="http://purl.org/coar/access_right" > </Access> </Publication> -1
score 13.253104
Doseresponse effect of black maca (Lepidium meyenii) in mice with memory impairment induced by ethanol
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La información contenida en este registro es de entera responsabilidad de la institución que gestiona el repositorio institucional donde esta contenido este documento o set de datos. El CONCYTEC no se hace responsable por los contenidos (publicaciones y/o datos) accesibles a través del Repositorio Nacional Digital de Ciencia, Tecnología e Innovación de Acceso Abierto (ALICIA).

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