Antibiotic resistance of Campylobacter species in a pediatric cohort study
Descripción del Articulo
The Etiology, Risk Factors, and Interactions of Enteric Infections and Malnutrition and the Consequences for Child Health and Development (MAL-ED) project was carried out as a collaborative project supported by the Bill & Melinda Gates Foundation (47075), the Foundation for the National Institut...
| Autores: | , , , , , , , |
|---|---|
| Formato: | artículo |
| Fecha de Publicación: | 2019 |
| Institución: | Consejo Nacional de Ciencia Tecnología e Innovación |
| Repositorio: | CONCYTEC-Institucional |
| Lenguaje: | inglés |
| OAI Identifier: | oai:repositorio.concytec.gob.pe:20.500.12390/516 |
| Enlace del recurso: | https://hdl.handle.net/20.500.12390/516 https://doi.org/10.1128/AAC.01911-18 |
| Nivel de acceso: | acceso abierto |
| Materia: | tetracycline ampicillin azithromycin ceftriaxone chloramphenicol ciprofloxacin clavulanic acid cotrimoxazole gentamicin macrolide nalidixic acid quinolone antibiotic resistance Article https://purl.org/pe-repo/ocde/ford#3.02.00 |
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CONCYTEC-Institucional |
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4689 |
| dc.title.none.fl_str_mv |
Antibiotic resistance of Campylobacter species in a pediatric cohort study |
| title |
Antibiotic resistance of Campylobacter species in a pediatric cohort study |
| spellingShingle |
Antibiotic resistance of Campylobacter species in a pediatric cohort study Schiaffino F. tetracycline ampicillin azithromycin ceftriaxone chloramphenicol ciprofloxacin clavulanic acid cotrimoxazole gentamicin macrolide nalidixic acid quinolone antibiotic resistance Article https://purl.org/pe-repo/ocde/ford#3.02.00 |
| title_short |
Antibiotic resistance of Campylobacter species in a pediatric cohort study |
| title_full |
Antibiotic resistance of Campylobacter species in a pediatric cohort study |
| title_fullStr |
Antibiotic resistance of Campylobacter species in a pediatric cohort study |
| title_full_unstemmed |
Antibiotic resistance of Campylobacter species in a pediatric cohort study |
| title_sort |
Antibiotic resistance of Campylobacter species in a pediatric cohort study |
| author |
Schiaffino F. |
| author_facet |
Schiaffino F. Colston J.M. Paredes-Olortegui M. François R. Pisanic N. Burga R. Peñataro-Yori P. Kosek M.N. |
| author_role |
author |
| author2 |
Colston J.M. Paredes-Olortegui M. François R. Pisanic N. Burga R. Peñataro-Yori P. Kosek M.N. |
| author2_role |
author author author author author author author |
| dc.contributor.author.fl_str_mv |
Schiaffino F. Colston J.M. Paredes-Olortegui M. François R. Pisanic N. Burga R. Peñataro-Yori P. Kosek M.N. |
| dc.subject.none.fl_str_mv |
tetracycline |
| topic |
tetracycline ampicillin azithromycin ceftriaxone chloramphenicol ciprofloxacin clavulanic acid cotrimoxazole gentamicin macrolide nalidixic acid quinolone antibiotic resistance Article https://purl.org/pe-repo/ocde/ford#3.02.00 |
| dc.subject.es_PE.fl_str_mv |
ampicillin azithromycin ceftriaxone chloramphenicol ciprofloxacin clavulanic acid cotrimoxazole gentamicin macrolide nalidixic acid quinolone antibiotic resistance Article |
| dc.subject.ocde.none.fl_str_mv |
https://purl.org/pe-repo/ocde/ford#3.02.00 |
| description |
The Etiology, Risk Factors, and Interactions of Enteric Infections and Malnutrition and the Consequences for Child Health and Development (MAL-ED) project was carried out as a collaborative project supported by the Bill & Melinda Gates Foundation (47075), the Foundation for the National Institutes of Health, and the National Institutes of Health, Fogarty International Center. M.N.K. was additionally supported by the Sherrilyn and Ken Fisher Center for Environmental Infectious Diseases of the Johns Hopkins School of Medicine (10POS2015). F.S. was supported by FONDECYT-CONCYTEC (grant contract number 246-2015-FONDECYT), and the National Institutes of Health Fogarty Global Health Fellows Consortium comprised of Johns Hopkins University, the University of North Carolina, Morehouse University, and Tulane University (grant no. D43TW009340). The funders had no role in study design, data collection and analysis, decision to publish, or preparation of the manuscript. We declare no conflict of interest. |
| publishDate |
2019 |
| dc.date.accessioned.none.fl_str_mv |
2024-05-30T23:13:38Z |
| dc.date.available.none.fl_str_mv |
2024-05-30T23:13:38Z |
| dc.date.issued.fl_str_mv |
2019 |
| dc.type.none.fl_str_mv |
info:eu-repo/semantics/article |
| format |
article |
| dc.identifier.uri.none.fl_str_mv |
https://hdl.handle.net/20.500.12390/516 |
| dc.identifier.doi.none.fl_str_mv |
https://doi.org/10.1128/AAC.01911-18 |
| dc.identifier.scopus.none.fl_str_mv |
2-s2.0-85060794284 |
| url |
https://hdl.handle.net/20.500.12390/516 https://doi.org/10.1128/AAC.01911-18 |
| identifier_str_mv |
2-s2.0-85060794284 |
| dc.language.iso.none.fl_str_mv |
eng |
| language |
eng |
| dc.relation.ispartof.none.fl_str_mv |
Antimicrobial Agents and Chemotherapy |
| dc.rights.none.fl_str_mv |
info:eu-repo/semantics/openAccess |
| dc.rights.uri.none.fl_str_mv |
https://creativecommons.org/licenses/by/4.0/ |
| eu_rights_str_mv |
openAccess |
| rights_invalid_str_mv |
https://creativecommons.org/licenses/by/4.0/ |
| dc.publisher.none.fl_str_mv |
American Society for Microbiology |
| publisher.none.fl_str_mv |
American Society for Microbiology |
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reponame:CONCYTEC-Institucional instname:Consejo Nacional de Ciencia Tecnología e Innovación instacron:CONCYTEC |
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Consejo Nacional de Ciencia Tecnología e Innovación |
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CONCYTEC |
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CONCYTEC |
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CONCYTEC-Institucional |
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CONCYTEC-Institucional |
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Repositorio Institucional CONCYTEC |
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repositorio@concytec.gob.pe |
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1839175608465096704 |
| spelling |
Publicationrp00715600rp00720600rp00719600rp00718600rp00716600rp00722600rp00717600rp00721600Schiaffino F.Colston J.M.Paredes-Olortegui M.François R.Pisanic N.Burga R.Peñataro-Yori P.Kosek M.N.2024-05-30T23:13:38Z2024-05-30T23:13:38Z2019https://hdl.handle.net/20.500.12390/516https://doi.org/10.1128/AAC.01911-182-s2.0-85060794284The Etiology, Risk Factors, and Interactions of Enteric Infections and Malnutrition and the Consequences for Child Health and Development (MAL-ED) project was carried out as a collaborative project supported by the Bill & Melinda Gates Foundation (47075), the Foundation for the National Institutes of Health, and the National Institutes of Health, Fogarty International Center. M.N.K. was additionally supported by the Sherrilyn and Ken Fisher Center for Environmental Infectious Diseases of the Johns Hopkins School of Medicine (10POS2015). F.S. was supported by FONDECYT-CONCYTEC (grant contract number 246-2015-FONDECYT), and the National Institutes of Health Fogarty Global Health Fellows Consortium comprised of Johns Hopkins University, the University of North Carolina, Morehouse University, and Tulane University (grant no. D43TW009340). The funders had no role in study design, data collection and analysis, decision to publish, or preparation of the manuscript. We declare no conflict of interest.The objective of this study was to determine the phenotypic patterns of antibiotic resistance and the epidemiology of drug-resistant Campylobacter spp. from a low-resource setting. A birth cohort of 303 patients was followed until 5 years of age. Stool samples from asymptomatic children (n = 10,008) and those with diarrhea (n = 3,175) were cultured for Campylobacter Disk diffusion for ciprofloxacin (CIP), nalidixic acid (NAL), erythromycin (ERY), azithromycin (AZM), tetracycline (TE), gentamicin (GM), ampicillin (AMP), amoxicillin and clavulanic acid (AMC), ceftriaxone (CRO), chloramphenicol (C), and trimethoprim-sulfamethoxazole (TMS) was determined. Antibiotic resistances in Campylobacter jejuni and non-C. jejuni isolates from surveillance and diarrhea samples were compared, and the association between personal macrolide exposure and subsequent occurrence of a macrolide-resistant Campylobacter spp. was assessed. Of 917 Campylobacter isolates, 77.4% of C. jejuni isolates and 79.8% of non-C. jejuni isolates were resistant to ciprofloxacin, while 4.9% of C. jejuni isolates and 24.8% of non-C. jejuni isolates were not susceptible to azithromycin. Of the 303 children, 33.1% had been diagnosed with a Campylobacter strain nonsusceptible to both azithromycin and ciprofloxacin. Personal macrolide exposure did not affect the risk of macrolide-resistant Campylobacter Amoxicillin and clavulanic acid (94.0%) was one of the antibiotics with the highest rates of susceptibility. There is a high incidence of quinolone- and macrolide-resistant Campylobacter infections in infants under 24 months of age. Given the lack of association between personal exposure to macrolides and a subsequent Campylobacter infection resistant to macrolides, there is a need to evaluate the source of multidrug-resistant (MDR) Campylobacter This study provides compelling evidence to propose amoxicillin/clavulanic acid as a treatment for campylobacteriosis.Consejo Nacional de Ciencia, Tecnología e Innovación Tecnológica - ConcytecengAmerican Society for MicrobiologyAntimicrobial Agents and Chemotherapyinfo:eu-repo/semantics/openAccesshttps://creativecommons.org/licenses/by/4.0/tetracyclineampicillin-1azithromycin-1ceftriaxone-1chloramphenicol-1ciprofloxacin-1clavulanic acid-1cotrimoxazole-1gentamicin-1macrolide-1nalidixic acid-1quinolone-1antibiotic resistance-1Article-1https://purl.org/pe-repo/ocde/ford#3.02.00-1Antibiotic resistance of Campylobacter species in a pediatric cohort studyinfo:eu-repo/semantics/articlereponame:CONCYTEC-Institucionalinstname:Consejo Nacional de Ciencia Tecnología e Innovacióninstacron:CONCYTEC#PLACEHOLDER_PARENT_METADATA_VALUE##PLACEHOLDER_PARENT_METADATA_VALUE##PLACEHOLDER_PARENT_METADATA_VALUE##PLACEHOLDER_PARENT_METADATA_VALUE##PLACEHOLDER_PARENT_METADATA_VALUE##PLACEHOLDER_PARENT_METADATA_VALUE##PLACEHOLDER_PARENT_METADATA_VALUE##PLACEHOLDER_PARENT_METADATA_VALUE#20.500.12390/516oai:repositorio.concytec.gob.pe:20.500.12390/5162024-05-30 15:22:01.893https://creativecommons.org/licenses/by/4.0/info:eu-repo/semantics/openAccesshttp://purl.org/coar/access_right/c_14cbinfo:eu-repo/semantics/closedAccessmetadata only accesshttps://repositorio.concytec.gob.peRepositorio Institucional CONCYTECrepositorio@concytec.gob.pe#PLACEHOLDER_PARENT_METADATA_VALUE##PLACEHOLDER_PARENT_METADATA_VALUE##PLACEHOLDER_PARENT_METADATA_VALUE##PLACEHOLDER_PARENT_METADATA_VALUE##PLACEHOLDER_PARENT_METADATA_VALUE##PLACEHOLDER_PARENT_METADATA_VALUE##PLACEHOLDER_PARENT_METADATA_VALUE##PLACEHOLDER_PARENT_METADATA_VALUE#<Publication xmlns="https://www.openaire.eu/cerif-profile/1.1/" id="78f64d30-eab4-4868-ba96-909a8d78149f"> <Type xmlns="https://www.openaire.eu/cerif-profile/vocab/COAR_Publication_Types">http://purl.org/coar/resource_type/c_1843</Type> <Language>eng</Language> <Title>Antibiotic resistance of Campylobacter species in a pediatric cohort study</Title> <PublishedIn> <Publication> <Title>Antimicrobial Agents and Chemotherapy</Title> </Publication> </PublishedIn> <PublicationDate>2019</PublicationDate> <DOI>https://doi.org/10.1128/AAC.01911-18</DOI> <SCP-Number>2-s2.0-85060794284</SCP-Number> <Authors> <Author> <DisplayName>Schiaffino F.</DisplayName> <Person id="rp00715" /> <Affiliation> <OrgUnit> </OrgUnit> </Affiliation> </Author> <Author> <DisplayName>Colston J.M.</DisplayName> <Person id="rp00720" /> <Affiliation> <OrgUnit> </OrgUnit> </Affiliation> </Author> <Author> <DisplayName>Paredes-Olortegui M.</DisplayName> <Person id="rp00719" /> <Affiliation> <OrgUnit> </OrgUnit> </Affiliation> </Author> <Author> <DisplayName>François R.</DisplayName> <Person id="rp00718" /> <Affiliation> <OrgUnit> </OrgUnit> </Affiliation> </Author> <Author> <DisplayName>Pisanic N.</DisplayName> <Person id="rp00716" /> <Affiliation> <OrgUnit> </OrgUnit> </Affiliation> </Author> <Author> <DisplayName>Burga R.</DisplayName> <Person id="rp00722" /> <Affiliation> <OrgUnit> </OrgUnit> </Affiliation> </Author> <Author> <DisplayName>Peñataro-Yori P.</DisplayName> <Person id="rp00717" /> <Affiliation> <OrgUnit> </OrgUnit> </Affiliation> </Author> <Author> <DisplayName>Kosek M.N.</DisplayName> <Person id="rp00721" /> <Affiliation> <OrgUnit> </OrgUnit> </Affiliation> </Author> </Authors> <Editors> </Editors> <Publishers> <Publisher> <DisplayName>American Society for Microbiology</DisplayName> <OrgUnit /> </Publisher> </Publishers> <License>https://creativecommons.org/licenses/by/4.0/</License> <Keyword>tetracycline</Keyword> <Keyword>ampicillin</Keyword> <Keyword>azithromycin</Keyword> <Keyword>ceftriaxone</Keyword> <Keyword>chloramphenicol</Keyword> <Keyword>ciprofloxacin</Keyword> <Keyword>clavulanic acid</Keyword> <Keyword>cotrimoxazole</Keyword> <Keyword>gentamicin</Keyword> <Keyword>macrolide</Keyword> <Keyword>nalidixic acid</Keyword> <Keyword>quinolone</Keyword> <Keyword>antibiotic resistance</Keyword> <Keyword>Article</Keyword> <Abstract>The objective of this study was to determine the phenotypic patterns of antibiotic resistance and the epidemiology of drug-resistant Campylobacter spp. from a low-resource setting. A birth cohort of 303 patients was followed until 5 years of age. Stool samples from asymptomatic children (n = 10,008) and those with diarrhea (n = 3,175) were cultured for Campylobacter Disk diffusion for ciprofloxacin (CIP), nalidixic acid (NAL), erythromycin (ERY), azithromycin (AZM), tetracycline (TE), gentamicin (GM), ampicillin (AMP), amoxicillin and clavulanic acid (AMC), ceftriaxone (CRO), chloramphenicol (C), and trimethoprim-sulfamethoxazole (TMS) was determined. Antibiotic resistances in Campylobacter jejuni and non-C. jejuni isolates from surveillance and diarrhea samples were compared, and the association between personal macrolide exposure and subsequent occurrence of a macrolide-resistant Campylobacter spp. was assessed. Of 917 Campylobacter isolates, 77.4% of C. jejuni isolates and 79.8% of non-C. jejuni isolates were resistant to ciprofloxacin, while 4.9% of C. jejuni isolates and 24.8% of non-C. jejuni isolates were not susceptible to azithromycin. Of the 303 children, 33.1% had been diagnosed with a Campylobacter strain nonsusceptible to both azithromycin and ciprofloxacin. Personal macrolide exposure did not affect the risk of macrolide-resistant Campylobacter Amoxicillin and clavulanic acid (94.0%) was one of the antibiotics with the highest rates of susceptibility. There is a high incidence of quinolone- and macrolide-resistant Campylobacter infections in infants under 24 months of age. Given the lack of association between personal exposure to macrolides and a subsequent Campylobacter infection resistant to macrolides, there is a need to evaluate the source of multidrug-resistant (MDR) Campylobacter This study provides compelling evidence to propose amoxicillin/clavulanic acid as a treatment for campylobacteriosis.</Abstract> <Access xmlns="http://purl.org/coar/access_right" > </Access> </Publication> -1 |
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Nota importante:
La información contenida en este registro es de entera responsabilidad de la institución que gestiona el repositorio institucional donde esta contenido este documento o set de datos. El CONCYTEC no se hace responsable por los contenidos (publicaciones y/o datos) accesibles a través del Repositorio Nacional Digital de Ciencia, Tecnología e Innovación de Acceso Abierto (ALICIA).
La información contenida en este registro es de entera responsabilidad de la institución que gestiona el repositorio institucional donde esta contenido este documento o set de datos. El CONCYTEC no se hace responsable por los contenidos (publicaciones y/o datos) accesibles a través del Repositorio Nacional Digital de Ciencia, Tecnología e Innovación de Acceso Abierto (ALICIA).
