Aging at high altitudes and the risk of chronic mountain sickness

Descripción del Articulo

ADEC/ATC (Peru) to A. Arregui and F. Leon-Velarde, and from CONCYTEC (Peru) to F. Leon-Velarde and C. Monge.
Detalles Bibliográficos
Autores: León-Velarde F., Arregui A., Monge C., Ruiz y Ruiz H.
Formato: artículo
Fecha de Publicación:1993
Institución:Consejo Nacional de Ciencia Tecnología e Innovación
Repositorio:CONCYTEC-Institucional
Lenguaje:inglés
OAI Identifier:oai:repositorio.concytec.gob.pe:20.500.12390/920
Enlace del recurso:https://hdl.handle.net/20.500.12390/920
https://doi.org/10.1580/0953-9859-4.2.183
Nivel de acceso:acceso abierto
Materia:Aparato respiratorio
https://purl.org/pe-repo/ocde/ford#3.02.07
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oai_identifier_str oai:repositorio.concytec.gob.pe:20.500.12390/920
network_acronym_str CONC
network_name_str CONCYTEC-Institucional
repository_id_str 4689
dc.title.none.fl_str_mv Aging at high altitudes and the risk of chronic mountain sickness
title Aging at high altitudes and the risk of chronic mountain sickness
spellingShingle Aging at high altitudes and the risk of chronic mountain sickness
León-Velarde F.
Aparato respiratorio
https://purl.org/pe-repo/ocde/ford#3.02.07
title_short Aging at high altitudes and the risk of chronic mountain sickness
title_full Aging at high altitudes and the risk of chronic mountain sickness
title_fullStr Aging at high altitudes and the risk of chronic mountain sickness
title_full_unstemmed Aging at high altitudes and the risk of chronic mountain sickness
title_sort Aging at high altitudes and the risk of chronic mountain sickness
author León-Velarde F.
author_facet León-Velarde F.
Arregui A.
Monge C.
Ruiz y Ruiz H.
author_role author
author2 Arregui A.
Monge C.
Ruiz y Ruiz H.
author2_role author
author
author
dc.contributor.author.fl_str_mv León-Velarde F.
Arregui A.
Monge C.
Ruiz y Ruiz H.
dc.subject.none.fl_str_mv Aparato respiratorio
topic Aparato respiratorio
https://purl.org/pe-repo/ocde/ford#3.02.07
dc.subject.ocde.none.fl_str_mv https://purl.org/pe-repo/ocde/ford#3.02.07
description ADEC/ATC (Peru) to A. Arregui and F. Leon-Velarde, and from CONCYTEC (Peru) to F. Leon-Velarde and C. Monge.
publishDate 1993
dc.date.accessioned.none.fl_str_mv 2024-05-30T23:13:38Z
dc.date.available.none.fl_str_mv 2024-05-30T23:13:38Z
dc.date.issued.fl_str_mv 1993
dc.type.none.fl_str_mv info:eu-repo/semantics/article
format article
dc.identifier.uri.none.fl_str_mv https://hdl.handle.net/20.500.12390/920
dc.identifier.doi.none.fl_str_mv https://doi.org/10.1580/0953-9859-4.2.183
dc.identifier.scopus.none.fl_str_mv 2-s2.0-0027207542
url https://hdl.handle.net/20.500.12390/920
https://doi.org/10.1580/0953-9859-4.2.183
identifier_str_mv 2-s2.0-0027207542
dc.language.iso.none.fl_str_mv eng
language eng
dc.rights.none.fl_str_mv info:eu-repo/semantics/openAccess
eu_rights_str_mv openAccess
dc.publisher.none.fl_str_mv Elsevier
publisher.none.fl_str_mv Elsevier
dc.source.none.fl_str_mv reponame:CONCYTEC-Institucional
instname:Consejo Nacional de Ciencia Tecnología e Innovación
instacron:CONCYTEC
instname_str Consejo Nacional de Ciencia Tecnología e Innovación
instacron_str CONCYTEC
institution CONCYTEC
reponame_str CONCYTEC-Institucional
collection CONCYTEC-Institucional
repository.name.fl_str_mv Repositorio Institucional CONCYTEC
repository.mail.fl_str_mv repositorio@concytec.gob.pe
_version_ 1839175754218209280
spelling Publicationrp01995500rp02024500rp02005500rp02422600León-Velarde F.Arregui A.Monge C.Ruiz y Ruiz H.2024-05-30T23:13:38Z2024-05-30T23:13:38Z1993https://hdl.handle.net/20.500.12390/920https://doi.org/10.1580/0953-9859-4.2.1832-s2.0-0027207542ADEC/ATC (Peru) to A. Arregui and F. Leon-Velarde, and from CONCYTEC (Peru) to F. Leon-Velarde and C. Monge.Clinical records of healthy high altitude (HA) (4300 m [14 100 ft]; n=2875) and sea level (SL) (n=2899) miners were examined for vital capacities (VC), body weights (W), heights (H), and hemoglobin (Hb) concentrations in different age groups. In the HA population, excessive erythrocytosis (EE) was defined as Hb ≥ 21.3 g dl−1; i.e., the mean Hb in the 20–29 age group plus 2 sd. This level of Hb is one of the parameters above which clinical chronic mountain sickness (CMS) becomes apparent. We found a smooth increasing prevalence of EE with age: 6.8% at age 20–29 to 33.7% at age 60–69. Height corrected VC (VC/H) decreases 3.0% between ages 20–29 and 60–69 years in SL miners and 26.5% in HA for the same age interval. In the latter, the pronounced decrease in VC/H is seen both in miners with EE (30.6%) and in those with physiological erythrocytosis (PE,22.4%). SL miners have significantly higher W/H ratios than do HA ones. This index steadily increases with age at SL. At HA, however, miners with EE and PE show a drop in their weights after ages 40–49 years. In addition, EE miners have higher W/H ratios than do PE ones between ages 40–59 years. We suggest that increasing Hb and diminishing VC with age at HA do not represent the so-called physiological adaptation. On the contrary, these may be risk factors for the development of CMS with age among HA Andean populations.Consejo Nacional de Ciencia, Tecnología e Innovación Tecnológica - ConcytecengElsevierinfo:eu-repo/semantics/openAccessAparato respiratoriohttps://purl.org/pe-repo/ocde/ford#3.02.07-1Aging at high altitudes and the risk of chronic mountain sicknessinfo:eu-repo/semantics/articlereponame:CONCYTEC-Institucionalinstname:Consejo Nacional de Ciencia Tecnología e Innovacióninstacron:CONCYTEC20.500.12390/920oai:repositorio.concytec.gob.pe:20.500.12390/9202024-05-30 15:59:49.83http://purl.org/coar/access_right/c_14cbinfo:eu-repo/semantics/closedAccessmetadata only accesshttps://repositorio.concytec.gob.peRepositorio Institucional CONCYTECrepositorio@concytec.gob.pe#PLACEHOLDER_PARENT_METADATA_VALUE##PLACEHOLDER_PARENT_METADATA_VALUE##PLACEHOLDER_PARENT_METADATA_VALUE##PLACEHOLDER_PARENT_METADATA_VALUE#<Publication xmlns="https://www.openaire.eu/cerif-profile/1.1/" id="cdfc7d21-7d6a-4857-9af5-6f485cfd78ff"> <Type xmlns="https://www.openaire.eu/cerif-profile/vocab/COAR_Publication_Types">http://purl.org/coar/resource_type/c_1843</Type> <Language>eng</Language> <Title>Aging at high altitudes and the risk of chronic mountain sickness</Title> <PublishedIn> <Publication> </Publication> </PublishedIn> <PublicationDate>1993</PublicationDate> <DOI>https://doi.org/10.1580/0953-9859-4.2.183</DOI> <SCP-Number>2-s2.0-0027207542</SCP-Number> <Authors> <Author> <DisplayName>León-Velarde F.</DisplayName> <Person id="rp01995" /> <Affiliation> <OrgUnit> </OrgUnit> </Affiliation> </Author> <Author> <DisplayName>Arregui A.</DisplayName> <Person id="rp02024" /> <Affiliation> <OrgUnit> </OrgUnit> </Affiliation> </Author> <Author> <DisplayName>Monge C.</DisplayName> <Person id="rp02005" /> <Affiliation> <OrgUnit> </OrgUnit> </Affiliation> </Author> <Author> <DisplayName>Ruiz y Ruiz H.</DisplayName> <Person id="rp02422" /> <Affiliation> <OrgUnit> </OrgUnit> </Affiliation> </Author> </Authors> <Editors> </Editors> <Publishers> <Publisher> <DisplayName>Elsevier</DisplayName> <OrgUnit /> </Publisher> </Publishers> <Keyword>Aparato respiratorio</Keyword> <Abstract>Clinical records of healthy high altitude (HA) (4300 m [14 100 ft]; n=2875) and sea level (SL) (n=2899) miners were examined for vital capacities (VC), body weights (W), heights (H), and hemoglobin (Hb) concentrations in different age groups. In the HA population, excessive erythrocytosis (EE) was defined as Hb ≥ 21.3 g dl−1; i.e., the mean Hb in the 20–29 age group plus 2 sd. This level of Hb is one of the parameters above which clinical chronic mountain sickness (CMS) becomes apparent. We found a smooth increasing prevalence of EE with age: 6.8% at age 20–29 to 33.7% at age 60–69. Height corrected VC (VC/H) decreases 3.0% between ages 20–29 and 60–69 years in SL miners and 26.5% in HA for the same age interval. In the latter, the pronounced decrease in VC/H is seen both in miners with EE (30.6%) and in those with physiological erythrocytosis (PE,22.4%). SL miners have significantly higher W/H ratios than do HA ones. This index steadily increases with age at SL. At HA, however, miners with EE and PE show a drop in their weights after ages 40–49 years. In addition, EE miners have higher W/H ratios than do PE ones between ages 40–59 years. We suggest that increasing Hb and diminishing VC with age at HA do not represent the so-called physiological adaptation. On the contrary, these may be risk factors for the development of CMS with age among HA Andean populations.</Abstract> <Access xmlns="http://purl.org/coar/access_right" > </Access> </Publication> -1
score 13.448642
Aging at high altitudes and the risk of chronic mountain sickness
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La información contenida en este registro es de entera responsabilidad de la institución que gestiona el repositorio institucional donde esta contenido este documento o set de datos. El CONCYTEC no se hace responsable por los contenidos (publicaciones y/o datos) accesibles a través del Repositorio Nacional Digital de Ciencia, Tecnología e Innovación de Acceso Abierto (ALICIA).

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