Diagnosis of Alzheimer's Disease in Developed and Developing Countries: Systematic Review and Meta-Analysis of Diagnostic Test Accuracy
Descripción del Articulo
This study was supported by the Consejo Nacional de Ciencia, Tecnologia e Innovacion y Tecnologia (CONCYTEC) and the Fondo Nacional de Desarrollo Cientifico, Tecnologico y de Innovacion Tecnologica de Peru (FONDECYT). Contract Nr. 24-2019. We would like to thank Dr. Maximo Rondon and Dra Karina Rosa...
| Autores: | , , , , , , , , , , , |
|---|---|
| Formato: | revisión |
| Fecha de Publicación: | 2021 |
| Institución: | Consejo Nacional de Ciencia Tecnología e Innovación |
| Repositorio: | CONCYTEC-Institucional |
| Lenguaje: | inglés |
| OAI Identifier: | oai:repositorio.concytec.gob.pe:20.500.12390/2928 |
| Enlace del recurso: | https://hdl.handle.net/20.500.12390/2928 https://doi.org/10.3233/ADR-200263 |
| Nivel de acceso: | acceso abierto |
| Materia: | systematic review Alzheimers disease diagnosis meta-analysis https://purl.org/pe-repo/ocde/ford#3.03.08 |
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oai:repositorio.concytec.gob.pe:20.500.12390/2928 |
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CONC |
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CONCYTEC-Institucional |
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4689 |
| dc.title.none.fl_str_mv |
Diagnosis of Alzheimer's Disease in Developed and Developing Countries: Systematic Review and Meta-Analysis of Diagnostic Test Accuracy |
| title |
Diagnosis of Alzheimer's Disease in Developed and Developing Countries: Systematic Review and Meta-Analysis of Diagnostic Test Accuracy |
| spellingShingle |
Diagnosis of Alzheimer's Disease in Developed and Developing Countries: Systematic Review and Meta-Analysis of Diagnostic Test Accuracy Chavez-Fumagalli, Miguel A. systematic review Alzheimers disease diagnosis meta-analysis https://purl.org/pe-repo/ocde/ford#3.03.08 |
| title_short |
Diagnosis of Alzheimer's Disease in Developed and Developing Countries: Systematic Review and Meta-Analysis of Diagnostic Test Accuracy |
| title_full |
Diagnosis of Alzheimer's Disease in Developed and Developing Countries: Systematic Review and Meta-Analysis of Diagnostic Test Accuracy |
| title_fullStr |
Diagnosis of Alzheimer's Disease in Developed and Developing Countries: Systematic Review and Meta-Analysis of Diagnostic Test Accuracy |
| title_full_unstemmed |
Diagnosis of Alzheimer's Disease in Developed and Developing Countries: Systematic Review and Meta-Analysis of Diagnostic Test Accuracy |
| title_sort |
Diagnosis of Alzheimer's Disease in Developed and Developing Countries: Systematic Review and Meta-Analysis of Diagnostic Test Accuracy |
| author |
Chavez-Fumagalli, Miguel A. |
| author_facet |
Chavez-Fumagalli, Miguel A. Shrivastava, Pallavi Aguilar-Pineda, Jorge A. Nieto-Montesinos, Rita Davila Del-Carpio, Gonzalo Peralta-Mestas, Antero Caracela-Zeballos, Claudia Valdez-Lazo, Guillermo Fernandez-Macedo, Victor Pino-Figueroa, Alejandro Vera-Lopez, Karin J. Lino Cardenas, Christian L. |
| author_role |
author |
| author2 |
Shrivastava, Pallavi Aguilar-Pineda, Jorge A. Nieto-Montesinos, Rita Davila Del-Carpio, Gonzalo Peralta-Mestas, Antero Caracela-Zeballos, Claudia Valdez-Lazo, Guillermo Fernandez-Macedo, Victor Pino-Figueroa, Alejandro Vera-Lopez, Karin J. Lino Cardenas, Christian L. |
| author2_role |
author author author author author author author author author author author |
| dc.contributor.author.fl_str_mv |
Chavez-Fumagalli, Miguel A. Shrivastava, Pallavi Aguilar-Pineda, Jorge A. Nieto-Montesinos, Rita Davila Del-Carpio, Gonzalo Peralta-Mestas, Antero Caracela-Zeballos, Claudia Valdez-Lazo, Guillermo Fernandez-Macedo, Victor Pino-Figueroa, Alejandro Vera-Lopez, Karin J. Lino Cardenas, Christian L. |
| dc.subject.none.fl_str_mv |
systematic review |
| topic |
systematic review Alzheimers disease diagnosis meta-analysis https://purl.org/pe-repo/ocde/ford#3.03.08 |
| dc.subject.es_PE.fl_str_mv |
Alzheimers disease diagnosis meta-analysis |
| dc.subject.ocde.none.fl_str_mv |
https://purl.org/pe-repo/ocde/ford#3.03.08 |
| description |
This study was supported by the Consejo Nacional de Ciencia, Tecnologia e Innovacion y Tecnologia (CONCYTEC) and the Fondo Nacional de Desarrollo Cientifico, Tecnologico y de Innovacion Tecnologica de Peru (FONDECYT). Contract Nr. 24-2019. We would like to thank Dr. Maximo Rondon and Dra Karina Rosas and theVicerrectorado de investigacion for providing substantial support to the Laboratory of Genomics and Neurovascular Diseases to carry out this work. |
| publishDate |
2021 |
| dc.date.accessioned.none.fl_str_mv |
2024-05-30T23:13:38Z |
| dc.date.available.none.fl_str_mv |
2024-05-30T23:13:38Z |
| dc.date.issued.fl_str_mv |
2021 |
| dc.type.none.fl_str_mv |
info:eu-repo/semantics/review |
| format |
review |
| dc.identifier.uri.none.fl_str_mv |
https://hdl.handle.net/20.500.12390/2928 |
| dc.identifier.doi.none.fl_str_mv |
https://doi.org/10.3233/ADR-200263 |
| url |
https://hdl.handle.net/20.500.12390/2928 https://doi.org/10.3233/ADR-200263 |
| dc.language.iso.none.fl_str_mv |
eng |
| language |
eng |
| dc.relation.ispartof.none.fl_str_mv |
JOURNAL OF ALZHEIMERS DISEASE REPORTS |
| dc.rights.none.fl_str_mv |
info:eu-repo/semantics/openAccess |
| dc.rights.uri.none.fl_str_mv |
https://creativecommons.org/licenses/by-nc-nd/4.0/ |
| eu_rights_str_mv |
openAccess |
| rights_invalid_str_mv |
https://creativecommons.org/licenses/by-nc-nd/4.0/ |
| dc.publisher.none.fl_str_mv |
IOS PRESS |
| publisher.none.fl_str_mv |
IOS PRESS |
| dc.source.none.fl_str_mv |
reponame:CONCYTEC-Institucional instname:Consejo Nacional de Ciencia Tecnología e Innovación instacron:CONCYTEC |
| instname_str |
Consejo Nacional de Ciencia Tecnología e Innovación |
| instacron_str |
CONCYTEC |
| institution |
CONCYTEC |
| reponame_str |
CONCYTEC-Institucional |
| collection |
CONCYTEC-Institucional |
| repository.name.fl_str_mv |
Repositorio Institucional CONCYTEC |
| repository.mail.fl_str_mv |
repositorio@concytec.gob.pe |
| _version_ |
1844883080003715072 |
| spelling |
Publicationrp08181600rp08182600rp08191600rp08188600rp08186600rp08187600rp08185600rp08190600rp08189600rp08184600rp08192600rp08183600Chavez-Fumagalli, Miguel A.Shrivastava, PallaviAguilar-Pineda, Jorge A.Nieto-Montesinos, RitaDavila Del-Carpio, GonzaloPeralta-Mestas, AnteroCaracela-Zeballos, ClaudiaValdez-Lazo, GuillermoFernandez-Macedo, VictorPino-Figueroa, AlejandroVera-Lopez, Karin J.Lino Cardenas, Christian L.2024-05-30T23:13:38Z2024-05-30T23:13:38Z2021https://hdl.handle.net/20.500.12390/2928https://doi.org/10.3233/ADR-200263This study was supported by the Consejo Nacional de Ciencia, Tecnologia e Innovacion y Tecnologia (CONCYTEC) and the Fondo Nacional de Desarrollo Cientifico, Tecnologico y de Innovacion Tecnologica de Peru (FONDECYT). Contract Nr. 24-2019. We would like to thank Dr. Maximo Rondon and Dra Karina Rosas and theVicerrectorado de investigacion for providing substantial support to the Laboratory of Genomics and Neurovascular Diseases to carry out this work.Background: The present systematic review and meta-analysis of diagnostic test accuracy summarizes the last three decades in advances on diagnosis of Alzheimer's disease (AD) in developed and developing countries. Objective: To determine the accuracy of biomarkers in diagnostic tools in AD, for example, cerebrospinal fluid, positron emission tomography (PET), and magnetic resonance imaging (MRI), etc. Methods: The authors searched PubMed for published studies from 1990 to April 2020 on AD diagnostic biomarkers. 84 published studies were pooled and analyzed in this meta-analysis and diagnostic accuracywas compared by summary receiver operating characteristic statistics. Results: Overall, 84 studies met the criteria and were included in a meta-analysis. For EEG, the sensitivity ranged from 67 to 98%, with a median of 80%, 95%CI [75, 91], tau-PET diagnosis sensitivity ranged from 76 to 97%, with a median of 94%, 95%CI [76, 97]; and MRI sensitivity ranged from 41 to 99%, with a median of 84%, 95%CI [81, 87]. Our results showed that tau-PET diagnosis had higher performance as compared to other diagnostic methods in this meta-analysis. Conclusion: Our findings showed an important discrepancy in diagnostic data for AD between developed and developing countries, which can impact global prevalence estimation and management of AD. Also, our analysis found a better performance for the tau-PET diagnostic over other methods to diagnose AD patients, but the expense of tau-PET scan seems to be the limiting factor in the diagnosis of AD in developing countries such as those found in Asia, Africa, and Latin America.Consejo Nacional de Ciencia, Tecnología e Innovación Tecnológica - ConcytecengIOS PRESSJOURNAL OF ALZHEIMERS DISEASE REPORTSinfo:eu-repo/semantics/openAccesshttps://creativecommons.org/licenses/by-nc-nd/4.0/systematic reviewAlzheimers disease-1diagnosis-1meta-analysis-1https://purl.org/pe-repo/ocde/ford#3.03.08-1Diagnosis of Alzheimer's Disease in Developed and Developing Countries: Systematic Review and Meta-Analysis of Diagnostic Test Accuracyinfo:eu-repo/semantics/reviewreponame:CONCYTEC-Institucionalinstname:Consejo Nacional de Ciencia Tecnología e Innovacióninstacron:CONCYTEC20.500.12390/2928oai:repositorio.concytec.gob.pe:20.500.12390/29282024-05-30 16:12:14.375https://creativecommons.org/licenses/by-nc-nd/4.0/info:eu-repo/semantics/openAccesshttp://purl.org/coar/access_right/c_14cbinfo:eu-repo/semantics/closedAccessmetadata only accesshttps://repositorio.concytec.gob.peRepositorio Institucional CONCYTECrepositorio@concytec.gob.pe#PLACEHOLDER_PARENT_METADATA_VALUE##PLACEHOLDER_PARENT_METADATA_VALUE##PLACEHOLDER_PARENT_METADATA_VALUE##PLACEHOLDER_PARENT_METADATA_VALUE##PLACEHOLDER_PARENT_METADATA_VALUE##PLACEHOLDER_PARENT_METADATA_VALUE##PLACEHOLDER_PARENT_METADATA_VALUE##PLACEHOLDER_PARENT_METADATA_VALUE##PLACEHOLDER_PARENT_METADATA_VALUE##PLACEHOLDER_PARENT_METADATA_VALUE##PLACEHOLDER_PARENT_METADATA_VALUE##PLACEHOLDER_PARENT_METADATA_VALUE#<Publication xmlns="https://www.openaire.eu/cerif-profile/1.1/" id="3d68166e-5661-4f29-a3c7-28a115b2d262"> <Type xmlns="https://www.openaire.eu/cerif-profile/vocab/COAR_Publication_Types">http://purl.org/coar/resource_type/c_1843</Type> <Language>eng</Language> <Title>Diagnosis of Alzheimer's Disease in Developed and Developing Countries: Systematic Review and Meta-Analysis of Diagnostic Test Accuracy</Title> <PublishedIn> <Publication> <Title>JOURNAL OF ALZHEIMERS DISEASE REPORTS</Title> </Publication> </PublishedIn> <PublicationDate>2021</PublicationDate> <DOI>https://doi.org/10.3233/ADR-200263</DOI> <Authors> <Author> <DisplayName>Chavez-Fumagalli, Miguel A.</DisplayName> <Person id="rp08181" /> <Affiliation> <OrgUnit> </OrgUnit> </Affiliation> </Author> <Author> <DisplayName>Shrivastava, Pallavi</DisplayName> <Person id="rp08182" /> <Affiliation> <OrgUnit> </OrgUnit> </Affiliation> </Author> <Author> <DisplayName>Aguilar-Pineda, Jorge A.</DisplayName> <Person id="rp08191" /> <Affiliation> <OrgUnit> </OrgUnit> </Affiliation> </Author> <Author> <DisplayName>Nieto-Montesinos, Rita</DisplayName> <Person id="rp08188" /> <Affiliation> <OrgUnit> </OrgUnit> </Affiliation> </Author> <Author> <DisplayName>Davila Del-Carpio, Gonzalo</DisplayName> <Person id="rp08186" /> <Affiliation> <OrgUnit> </OrgUnit> </Affiliation> </Author> <Author> <DisplayName>Peralta-Mestas, Antero</DisplayName> <Person id="rp08187" /> <Affiliation> <OrgUnit> </OrgUnit> </Affiliation> </Author> <Author> <DisplayName>Caracela-Zeballos, Claudia</DisplayName> <Person id="rp08185" /> <Affiliation> <OrgUnit> </OrgUnit> </Affiliation> </Author> <Author> <DisplayName>Valdez-Lazo, Guillermo</DisplayName> <Person id="rp08190" /> <Affiliation> <OrgUnit> </OrgUnit> </Affiliation> </Author> <Author> <DisplayName>Fernandez-Macedo, Victor</DisplayName> <Person id="rp08189" /> <Affiliation> <OrgUnit> </OrgUnit> </Affiliation> </Author> <Author> <DisplayName>Pino-Figueroa, Alejandro</DisplayName> <Person id="rp08184" /> <Affiliation> <OrgUnit> </OrgUnit> </Affiliation> </Author> <Author> <DisplayName>Vera-Lopez, Karin J.</DisplayName> <Person id="rp08192" /> <Affiliation> <OrgUnit> </OrgUnit> </Affiliation> </Author> <Author> <DisplayName>Lino Cardenas, Christian L.</DisplayName> <Person id="rp08183" /> <Affiliation> <OrgUnit> </OrgUnit> </Affiliation> </Author> </Authors> <Editors> </Editors> <Publishers> <Publisher> <DisplayName>IOS PRESS</DisplayName> <OrgUnit /> </Publisher> </Publishers> <License>https://creativecommons.org/licenses/by-nc-nd/4.0/</License> <Keyword>systematic review</Keyword> <Keyword>Alzheimers disease</Keyword> <Keyword>diagnosis</Keyword> <Keyword>meta-analysis</Keyword> <Abstract>Background: The present systematic review and meta-analysis of diagnostic test accuracy summarizes the last three decades in advances on diagnosis of Alzheimer's disease (AD) in developed and developing countries. Objective: To determine the accuracy of biomarkers in diagnostic tools in AD, for example, cerebrospinal fluid, positron emission tomography (PET), and magnetic resonance imaging (MRI), etc. Methods: The authors searched PubMed for published studies from 1990 to April 2020 on AD diagnostic biomarkers. 84 published studies were pooled and analyzed in this meta-analysis and diagnostic accuracywas compared by summary receiver operating characteristic statistics. Results: Overall, 84 studies met the criteria and were included in a meta-analysis. For EEG, the sensitivity ranged from 67 to 98%, with a median of 80%, 95%CI [75, 91], tau-PET diagnosis sensitivity ranged from 76 to 97%, with a median of 94%, 95%CI [76, 97]; and MRI sensitivity ranged from 41 to 99%, with a median of 84%, 95%CI [81, 87]. Our results showed that tau-PET diagnosis had higher performance as compared to other diagnostic methods in this meta-analysis. Conclusion: Our findings showed an important discrepancy in diagnostic data for AD between developed and developing countries, which can impact global prevalence estimation and management of AD. Also, our analysis found a better performance for the tau-PET diagnostic over other methods to diagnose AD patients, but the expense of tau-PET scan seems to be the limiting factor in the diagnosis of AD in developing countries such as those found in Asia, Africa, and Latin America.</Abstract> <Access xmlns="http://purl.org/coar/access_right" > </Access> </Publication> -1 |
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13.394457 |
Nota importante:
La información contenida en este registro es de entera responsabilidad de la institución que gestiona el repositorio institucional donde esta contenido este documento o set de datos. El CONCYTEC no se hace responsable por los contenidos (publicaciones y/o datos) accesibles a través del Repositorio Nacional Digital de Ciencia, Tecnología e Innovación de Acceso Abierto (ALICIA).
La información contenida en este registro es de entera responsabilidad de la institución que gestiona el repositorio institucional donde esta contenido este documento o set de datos. El CONCYTEC no se hace responsable por los contenidos (publicaciones y/o datos) accesibles a través del Repositorio Nacional Digital de Ciencia, Tecnología e Innovación de Acceso Abierto (ALICIA).
