Chemical composition and in vitro antiplasmodial activity of the total alkaloids of the bulbs of two amaryllidaceae species from Northern Peru
Descripción del Articulo
We thank the Fondo Nacional de Desarrollo Científico, Tecnológico y de Innovación Tecnológica (FONDECYT) del Consejo Nacional de Ciencia Tecnología e Innovación Tecnologica (CONCYTEC-Perú) Grants Nº 110 -2018 - FONDECYT, for financial support to this study. The authors thank the Programa Iberoameric...
| Autores: | , , , |
|---|---|
| Formato: | artículo |
| Fecha de Publicación: | 2021 |
| Institución: | Consejo Nacional de Ciencia Tecnología e Innovación |
| Repositorio: | CONCYTEC-Institucional |
| Lenguaje: | inglés |
| OAI Identifier: | oai:repositorio.concytec.gob.pe:20.500.12390/2980 |
| Enlace del recurso: | https://hdl.handle.net/20.500.12390/2980 https://doi.org/10.5530/pj.2021.13.135 |
| Nivel de acceso: | acceso abierto |
| Materia: | Plasmodium falciparum Clinanthus incarnatus Clinanthus ruber https://purl.org/pe-repo/ocde/ford#2.04.01 |
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| dc.title.none.fl_str_mv |
Chemical composition and in vitro antiplasmodial activity of the total alkaloids of the bulbs of two amaryllidaceae species from Northern Peru |
| title |
Chemical composition and in vitro antiplasmodial activity of the total alkaloids of the bulbs of two amaryllidaceae species from Northern Peru |
| spellingShingle |
Chemical composition and in vitro antiplasmodial activity of the total alkaloids of the bulbs of two amaryllidaceae species from Northern Peru Soto-Vásquez M.R. Plasmodium falciparum Clinanthus incarnatus Clinanthus ruber https://purl.org/pe-repo/ocde/ford#2.04.01 |
| title_short |
Chemical composition and in vitro antiplasmodial activity of the total alkaloids of the bulbs of two amaryllidaceae species from Northern Peru |
| title_full |
Chemical composition and in vitro antiplasmodial activity of the total alkaloids of the bulbs of two amaryllidaceae species from Northern Peru |
| title_fullStr |
Chemical composition and in vitro antiplasmodial activity of the total alkaloids of the bulbs of two amaryllidaceae species from Northern Peru |
| title_full_unstemmed |
Chemical composition and in vitro antiplasmodial activity of the total alkaloids of the bulbs of two amaryllidaceae species from Northern Peru |
| title_sort |
Chemical composition and in vitro antiplasmodial activity of the total alkaloids of the bulbs of two amaryllidaceae species from Northern Peru |
| author |
Soto-Vásquez M.R. |
| author_facet |
Soto-Vásquez M.R. Pinedo M.V.H. Tallini L.R. Bastida J. |
| author_role |
author |
| author2 |
Pinedo M.V.H. Tallini L.R. Bastida J. |
| author2_role |
author author author |
| dc.contributor.author.fl_str_mv |
Soto-Vásquez M.R. Pinedo M.V.H. Tallini L.R. Bastida J. |
| dc.subject.none.fl_str_mv |
Plasmodium falciparum |
| topic |
Plasmodium falciparum Clinanthus incarnatus Clinanthus ruber https://purl.org/pe-repo/ocde/ford#2.04.01 |
| dc.subject.es_PE.fl_str_mv |
Clinanthus incarnatus Clinanthus ruber |
| dc.subject.ocde.none.fl_str_mv |
https://purl.org/pe-repo/ocde/ford#2.04.01 |
| description |
We thank the Fondo Nacional de Desarrollo Científico, Tecnológico y de Innovación Tecnológica (FONDECYT) del Consejo Nacional de Ciencia Tecnología e Innovación Tecnologica (CONCYTEC-Perú) Grants Nº 110 -2018 - FONDECYT, for financial support to this study. The authors thank the Programa Iberoamericano de Ciencia y Tecnología para el Desarrollo (CYTED) for providing the framework. |
| publishDate |
2021 |
| dc.date.accessioned.none.fl_str_mv |
2024-05-30T23:13:38Z |
| dc.date.available.none.fl_str_mv |
2024-05-30T23:13:38Z |
| dc.date.issued.fl_str_mv |
2021 |
| dc.type.none.fl_str_mv |
info:eu-repo/semantics/article |
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article |
| dc.identifier.uri.none.fl_str_mv |
https://hdl.handle.net/20.500.12390/2980 |
| dc.identifier.doi.none.fl_str_mv |
https://doi.org/10.5530/pj.2021.13.135 |
| dc.identifier.scopus.none.fl_str_mv |
2-s2.0-85110970330 |
| url |
https://hdl.handle.net/20.500.12390/2980 https://doi.org/10.5530/pj.2021.13.135 |
| identifier_str_mv |
2-s2.0-85110970330 |
| dc.language.iso.none.fl_str_mv |
eng |
| language |
eng |
| dc.relation.ispartof.none.fl_str_mv |
Pharmacognosy Journal |
| dc.rights.none.fl_str_mv |
info:eu-repo/semantics/openAccess |
| eu_rights_str_mv |
openAccess |
| dc.publisher.none.fl_str_mv |
EManuscript Technologies |
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EManuscript Technologies |
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reponame:CONCYTEC-Institucional instname:Consejo Nacional de Ciencia Tecnología e Innovación instacron:CONCYTEC |
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Consejo Nacional de Ciencia Tecnología e Innovación |
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CONCYTEC |
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CONCYTEC |
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CONCYTEC-Institucional |
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CONCYTEC-Institucional |
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Repositorio Institucional CONCYTEC |
| repository.mail.fl_str_mv |
repositorio@concytec.gob.pe |
| _version_ |
1844882996741537792 |
| spelling |
Publicationrp08450600rp08449600rp08448600rp08447600Soto-Vásquez M.R.Pinedo M.V.H.Tallini L.R.Bastida J.2024-05-30T23:13:38Z2024-05-30T23:13:38Z2021https://hdl.handle.net/20.500.12390/2980https://doi.org/10.5530/pj.2021.13.1352-s2.0-85110970330We thank the Fondo Nacional de Desarrollo Científico, Tecnológico y de Innovación Tecnológica (FONDECYT) del Consejo Nacional de Ciencia Tecnología e Innovación Tecnologica (CONCYTEC-Perú) Grants Nº 110 -2018 - FONDECYT, for financial support to this study. The authors thank the Programa Iberoamericano de Ciencia y Tecnología para el Desarrollo (CYTED) for providing the framework.Introduction: The amaryllidaceae family is characterized by presenting alkaloids with powerful pharmacological activities, including antiprotozoal activity. The aim of the present work was to determine the chemical composition and evaluate the in vitro antiplasmodial activity of the total alkaloids of the bulbs of two amaryllidaceae species from northern Perú. Methods: The total alkaloids were extracted from the bulbs using an acid-base extraction. The chemical composition of the total alkaloids was determined by GC-MS, using galantamine as a reference standard. It was investigated the in vitro antiplasmodial activity against Plasmodium falciparum FCR-3 strain (chloroquine-resistant). Results: 8 alkaloids were identified in the bulbs of Clinanthus incarnatus: lycorine, galanthamine, galanthine, vittatine/crinine, hippamine, 3-O-acetylpowelline, 11,12-dehydroanhydrolycorine, 1-O-acetyllycorine with values of 19.73; 14.99; 10.36; 10.22; 10.16; 10.14; 10.04; 9.85 µg GAL/100 mg of total alkaloid (TA) respectively and 6 alkaloids in the bulbs of Clinanthus ruber: lycorine, anhydrolycorine, 11,12-dehydroanhydrolycorine, 2,4-didehydro-2-dehydroxylycorine, 8-0-dimethylmaritidine, hippamine, with values of 70.2; 18; 4.15; 3.45; 6.8 and 0.1 µg GAL/100 mg TA respectively. The total alkaloids of the species of C. incarnatus and C. ruber at concentrations of 1.0; 2.5; 5.0; 10.0; 25.0 and 50.0 µg/ml presented inhibition percentages of 23.5 ± 0.46% to 94 ± 0.56% against P. falciparum with (p <0.05). They also presented IC50 0.375 µg/ml (C. incarnatus) and IC50 0.241 µg / ml (C. ruber). Conclusion: The main component of total alkaloids of the bulbs of two species was lycorine, in adittion, these species showed in vitro antiplasmoidal activity against Plasmodium falciparum FCR-3 strain at the doses tested. © 2021 Phcogj.Com. This is an open-access article distributed under the terms of the Creative Commons Attribution 4.0 International license.Consejo Nacional de Ciencia, Tecnología e Innovación Tecnológica - ConcytecengEManuscript TechnologiesPharmacognosy Journalinfo:eu-repo/semantics/openAccessPlasmodium falciparumClinanthus incarnatus-1Clinanthus ruber-1https://purl.org/pe-repo/ocde/ford#2.04.01-1Chemical composition and in vitro antiplasmodial activity of the total alkaloids of the bulbs of two amaryllidaceae species from Northern Peruinfo:eu-repo/semantics/articlereponame:CONCYTEC-Institucionalinstname:Consejo Nacional de Ciencia Tecnología e Innovacióninstacron:CONCYTEC20.500.12390/2980oai:repositorio.concytec.gob.pe:20.500.12390/29802024-05-30 16:12:45.967http://purl.org/coar/access_right/c_14cbinfo:eu-repo/semantics/closedAccessmetadata only accesshttps://repositorio.concytec.gob.peRepositorio Institucional CONCYTECrepositorio@concytec.gob.pe#PLACEHOLDER_PARENT_METADATA_VALUE##PLACEHOLDER_PARENT_METADATA_VALUE##PLACEHOLDER_PARENT_METADATA_VALUE##PLACEHOLDER_PARENT_METADATA_VALUE#<Publication xmlns="https://www.openaire.eu/cerif-profile/1.1/" id="8b02636f-fd1f-447d-856f-9bd1b47d88c7"> <Type xmlns="https://www.openaire.eu/cerif-profile/vocab/COAR_Publication_Types">http://purl.org/coar/resource_type/c_1843</Type> <Language>eng</Language> <Title>Chemical composition and in vitro antiplasmodial activity of the total alkaloids of the bulbs of two amaryllidaceae species from Northern Peru</Title> <PublishedIn> <Publication> <Title>Pharmacognosy Journal</Title> </Publication> </PublishedIn> <PublicationDate>2021</PublicationDate> <DOI>https://doi.org/10.5530/pj.2021.13.135</DOI> <SCP-Number>2-s2.0-85110970330</SCP-Number> <Authors> <Author> <DisplayName>Soto-Vásquez M.R.</DisplayName> <Person id="rp08450" /> <Affiliation> <OrgUnit> </OrgUnit> </Affiliation> </Author> <Author> <DisplayName>Pinedo M.V.H.</DisplayName> <Person id="rp08449" /> <Affiliation> <OrgUnit> </OrgUnit> </Affiliation> </Author> <Author> <DisplayName>Tallini L.R.</DisplayName> <Person id="rp08448" /> <Affiliation> <OrgUnit> </OrgUnit> </Affiliation> </Author> <Author> <DisplayName>Bastida J.</DisplayName> <Person id="rp08447" /> <Affiliation> <OrgUnit> </OrgUnit> </Affiliation> </Author> </Authors> <Editors> </Editors> <Publishers> <Publisher> <DisplayName>EManuscript Technologies</DisplayName> <OrgUnit /> </Publisher> </Publishers> <Keyword>Plasmodium falciparum</Keyword> <Keyword>Clinanthus incarnatus</Keyword> <Keyword>Clinanthus ruber</Keyword> <Abstract>Introduction: The amaryllidaceae family is characterized by presenting alkaloids with powerful pharmacological activities, including antiprotozoal activity. The aim of the present work was to determine the chemical composition and evaluate the in vitro antiplasmodial activity of the total alkaloids of the bulbs of two amaryllidaceae species from northern Perú. Methods: The total alkaloids were extracted from the bulbs using an acid-base extraction. The chemical composition of the total alkaloids was determined by GC-MS, using galantamine as a reference standard. It was investigated the in vitro antiplasmodial activity against Plasmodium falciparum FCR-3 strain (chloroquine-resistant). Results: 8 alkaloids were identified in the bulbs of Clinanthus incarnatus: lycorine, galanthamine, galanthine, vittatine/crinine, hippamine, 3-O-acetylpowelline, 11,12-dehydroanhydrolycorine, 1-O-acetyllycorine with values of 19.73; 14.99; 10.36; 10.22; 10.16; 10.14; 10.04; 9.85 µg GAL/100 mg of total alkaloid (TA) respectively and 6 alkaloids in the bulbs of Clinanthus ruber: lycorine, anhydrolycorine, 11,12-dehydroanhydrolycorine, 2,4-didehydro-2-dehydroxylycorine, 8-0-dimethylmaritidine, hippamine, with values of 70.2; 18; 4.15; 3.45; 6.8 and 0.1 µg GAL/100 mg TA respectively. The total alkaloids of the species of C. incarnatus and C. ruber at concentrations of 1.0; 2.5; 5.0; 10.0; 25.0 and 50.0 µg/ml presented inhibition percentages of 23.5 ± 0.46% to 94 ± 0.56% against P. falciparum with (p &lt;0.05). They also presented IC50 0.375 µg/ml (C. incarnatus) and IC50 0.241 µg / ml (C. ruber). Conclusion: The main component of total alkaloids of the bulbs of two species was lycorine, in adittion, these species showed in vitro antiplasmoidal activity against Plasmodium falciparum FCR-3 strain at the doses tested. © 2021 Phcogj.Com. This is an open-access article distributed under the terms of the Creative Commons Attribution 4.0 International license.</Abstract> <Access xmlns="http://purl.org/coar/access_right" > </Access> </Publication> -1 |
| score |
13.394457 |
Nota importante:
La información contenida en este registro es de entera responsabilidad de la institución que gestiona el repositorio institucional donde esta contenido este documento o set de datos. El CONCYTEC no se hace responsable por los contenidos (publicaciones y/o datos) accesibles a través del Repositorio Nacional Digital de Ciencia, Tecnología e Innovación de Acceso Abierto (ALICIA).
La información contenida en este registro es de entera responsabilidad de la institución que gestiona el repositorio institucional donde esta contenido este documento o set de datos. El CONCYTEC no se hace responsable por los contenidos (publicaciones y/o datos) accesibles a través del Repositorio Nacional Digital de Ciencia, Tecnología e Innovación de Acceso Abierto (ALICIA).
