Antileishmanial, antitrypanosomal, and cytotoxic screening of ethnopharmacologically selected Peruvian plants

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This work was supported by grant CTQ2009-14629-C02-01 (Spain) and a collaborative research project CSIC-CONCYTEC (Peru). We also thank S. Carlin for language revision.
Detalles Bibliográficos
Autores: Gonzalez-Coloma, A, Reina, M, Saenz, C, Lacret, R, Ruiz-Mesia, L, Aran, VJ, Sanz, J, Martinez-Diaz, RA
Formato: artículo
Fecha de Publicación:2012
Institución:Consejo Nacional de Ciencia Tecnología e Innovación
Repositorio:CONCYTEC-Institucional
Lenguaje:inglés
OAI Identifier:oai:repositorio.concytec.gob.pe:20.500.12390/1126
Enlace del recurso:https://hdl.handle.net/20.500.12390/1126
https://doi.org/10.1007/s00436-011-2638-3
Nivel de acceso:acceso abierto
Materia:Perú
Biologia
Farmacologia
https://purl.org/pe-repo/ocde/ford#1.06.00
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oai_identifier_str oai:repositorio.concytec.gob.pe:20.500.12390/1126
network_acronym_str CONC
network_name_str CONCYTEC-Institucional
repository_id_str 4689
dc.title.none.fl_str_mv Antileishmanial, antitrypanosomal, and cytotoxic screening of ethnopharmacologically selected Peruvian plants
title Antileishmanial, antitrypanosomal, and cytotoxic screening of ethnopharmacologically selected Peruvian plants
spellingShingle Antileishmanial, antitrypanosomal, and cytotoxic screening of ethnopharmacologically selected Peruvian plants
Gonzalez-Coloma, A
Perú
Biologia
Farmacologia
https://purl.org/pe-repo/ocde/ford#1.06.00
title_short Antileishmanial, antitrypanosomal, and cytotoxic screening of ethnopharmacologically selected Peruvian plants
title_full Antileishmanial, antitrypanosomal, and cytotoxic screening of ethnopharmacologically selected Peruvian plants
title_fullStr Antileishmanial, antitrypanosomal, and cytotoxic screening of ethnopharmacologically selected Peruvian plants
title_full_unstemmed Antileishmanial, antitrypanosomal, and cytotoxic screening of ethnopharmacologically selected Peruvian plants
title_sort Antileishmanial, antitrypanosomal, and cytotoxic screening of ethnopharmacologically selected Peruvian plants
author Gonzalez-Coloma, A
author_facet Gonzalez-Coloma, A
Reina, M
Saenz, C
Lacret, R
Ruiz-Mesia, L
Aran, VJ
Sanz, J
Martinez-Diaz, RA
author_role author
author2 Reina, M
Saenz, C
Lacret, R
Ruiz-Mesia, L
Aran, VJ
Sanz, J
Martinez-Diaz, RA
author2_role author
author
author
author
author
author
author
dc.contributor.author.fl_str_mv Gonzalez-Coloma, A
Reina, M
Saenz, C
Lacret, R
Ruiz-Mesia, L
Aran, VJ
Sanz, J
Martinez-Diaz, RA
dc.subject.none.fl_str_mv Perú
topic Perú
Biologia
Farmacologia
https://purl.org/pe-repo/ocde/ford#1.06.00
dc.subject.es_PE.fl_str_mv Biologia
Farmacologia
dc.subject.ocde.none.fl_str_mv https://purl.org/pe-repo/ocde/ford#1.06.00
description This work was supported by grant CTQ2009-14629-C02-01 (Spain) and a collaborative research project CSIC-CONCYTEC (Peru). We also thank S. Carlin for language revision.
publishDate 2012
dc.date.accessioned.none.fl_str_mv 2024-05-30T23:13:38Z
dc.date.available.none.fl_str_mv 2024-05-30T23:13:38Z
dc.date.issued.fl_str_mv 2012
dc.type.none.fl_str_mv info:eu-repo/semantics/article
format article
dc.identifier.uri.none.fl_str_mv https://hdl.handle.net/20.500.12390/1126
dc.identifier.doi.none.fl_str_mv https://doi.org/10.1007/s00436-011-2638-3
dc.identifier.isi.none.fl_str_mv 302814500009
url https://hdl.handle.net/20.500.12390/1126
https://doi.org/10.1007/s00436-011-2638-3
identifier_str_mv 302814500009
dc.language.iso.none.fl_str_mv eng
language eng
dc.relation.ispartof.none.fl_str_mv Parasitology Research
dc.rights.none.fl_str_mv info:eu-repo/semantics/openAccess
eu_rights_str_mv openAccess
dc.publisher.none.fl_str_mv Parasitology Research
publisher.none.fl_str_mv Parasitology Research
dc.source.none.fl_str_mv reponame:CONCYTEC-Institucional
instname:Consejo Nacional de Ciencia Tecnología e Innovación
instacron:CONCYTEC
instname_str Consejo Nacional de Ciencia Tecnología e Innovación
instacron_str CONCYTEC
institution CONCYTEC
reponame_str CONCYTEC-Institucional
collection CONCYTEC-Institucional
repository.name.fl_str_mv Repositorio Institucional CONCYTEC
repository.mail.fl_str_mv repositorio@concytec.gob.pe
_version_ 1844883050881613824
spelling Publicationrp03173600rp03170600rp03171600rp03172600rp03176600rp03174600rp03177600rp03175600Gonzalez-Coloma, AReina, MSaenz, CLacret, RRuiz-Mesia, LAran, VJSanz, JMartinez-Diaz, RA2024-05-30T23:13:38Z2024-05-30T23:13:38Z2012https://hdl.handle.net/20.500.12390/1126https://doi.org/10.1007/s00436-011-2638-3302814500009This work was supported by grant CTQ2009-14629-C02-01 (Spain) and a collaborative research project CSIC-CONCYTEC (Peru). We also thank S. Carlin for language revision.Extracts (34) from eight plant species of the Peruvian Amazonia currently used in traditional Peruvian medicine, mostly as antileishmanial remedies and also as painkiller, antiseptic, antipyretic, anti-inflamatory, antiflu, astringent, diuretic, antipoison, anticancerous, antiparasitic, insecticidal, or healing agents, have been tested for their antileishmanial, antitrypanosomal, and cytotoxic activity. Plant species were selected based on interviews conducted with residents of rural areas. The different plant parts were dried, powdered, and extracted by maceration with different solvents (hexane, chloroform, and 70% ethanol–water). These extracts were tested on promastigote forms of Leishmania infantum strain PB75, epimastigote forms of Trypanosoma cruzi strain Y, and the mammalian CHO cell line. Parasite viability and nonspecific cytotoxicity were analyzed by a modified MTT colorimetric assay method. The isolation and identification of pure compounds from selected extracts were performed by column chromatography, gas chromatography mass spectrometry (GC-MS; mixtures), spectroscopic techniques [MS, infrared (IR), ultraviolet (UV)], and mono and two-dimensional 1H and 13C nuclear magnetic resonance (NMR; COSY, HSQC, NOESY) experiments. Chondodendron tomentosum bark and Cedrela odorata were the most active extracts against Leishmania, while C. odorata and Aristoloquia pilosa were the most active against Trypanosoma, followed by Tabebuia serratifolia, Tradescantia zebrina, and Zamia ulei. Six compounds and two mixtures were isolated from Z. ulei [cycasin (1)], T. serratifolia {mixtures 1–2, and naphthoquinones 2-acetyl-4H,9H-naphtho[2,3-b]furan-4,9-dione (2) and 2-(1-hydroxyethyl)-4H,9H-naphtho[2,3-b]furan-4,9-dione (3)}, and C. tomentosum [chondrocurine (4); (S,S′)-12-O-methyl(+)-curine (5); and cycleanine (6)]. Four compounds and the two mixtures exhibited significant activity.Consejo Nacional de Ciencia, Tecnología e Innovación Tecnológica - ConcytecengParasitology ResearchParasitology Researchinfo:eu-repo/semantics/openAccessPerúBiologia-1Farmacologia-1https://purl.org/pe-repo/ocde/ford#1.06.00-1Antileishmanial, antitrypanosomal, and cytotoxic screening of ethnopharmacologically selected Peruvian plantsinfo:eu-repo/semantics/articlereponame:CONCYTEC-Institucionalinstname:Consejo Nacional de Ciencia Tecnología e Innovacióninstacron:CONCYTEC20.500.12390/1126oai:repositorio.concytec.gob.pe:20.500.12390/11262024-05-30 16:01:20.585http://purl.org/coar/access_right/c_14cbinfo:eu-repo/semantics/closedAccessmetadata only accesshttps://repositorio.concytec.gob.peRepositorio Institucional CONCYTECrepositorio@concytec.gob.pe#PLACEHOLDER_PARENT_METADATA_VALUE##PLACEHOLDER_PARENT_METADATA_VALUE##PLACEHOLDER_PARENT_METADATA_VALUE##PLACEHOLDER_PARENT_METADATA_VALUE##PLACEHOLDER_PARENT_METADATA_VALUE##PLACEHOLDER_PARENT_METADATA_VALUE##PLACEHOLDER_PARENT_METADATA_VALUE##PLACEHOLDER_PARENT_METADATA_VALUE#<Publication xmlns="https://www.openaire.eu/cerif-profile/1.1/" id="05e41f28-f93b-4b88-abdc-2c54c6a779c7"> <Type xmlns="https://www.openaire.eu/cerif-profile/vocab/COAR_Publication_Types">http://purl.org/coar/resource_type/c_1843</Type> <Language>eng</Language> <Title>Antileishmanial, antitrypanosomal, and cytotoxic screening of ethnopharmacologically selected Peruvian plants</Title> <PublishedIn> <Publication> <Title>Parasitology Research</Title> </Publication> </PublishedIn> <PublicationDate>2012</PublicationDate> <DOI>https://doi.org/10.1007/s00436-011-2638-3</DOI> <ISI-Number>302814500009</ISI-Number> <Authors> <Author> <DisplayName>Gonzalez-Coloma, A</DisplayName> <Person id="rp03173" /> <Affiliation> <OrgUnit> </OrgUnit> </Affiliation> </Author> <Author> <DisplayName>Reina, M</DisplayName> <Person id="rp03170" /> <Affiliation> <OrgUnit> </OrgUnit> </Affiliation> </Author> <Author> <DisplayName>Saenz, C</DisplayName> <Person id="rp03171" /> <Affiliation> <OrgUnit> </OrgUnit> </Affiliation> </Author> <Author> <DisplayName>Lacret, R</DisplayName> <Person id="rp03172" /> <Affiliation> <OrgUnit> </OrgUnit> </Affiliation> </Author> <Author> <DisplayName>Ruiz-Mesia, L</DisplayName> <Person id="rp03176" /> <Affiliation> <OrgUnit> </OrgUnit> </Affiliation> </Author> <Author> <DisplayName>Aran, VJ</DisplayName> <Person id="rp03174" /> <Affiliation> <OrgUnit> </OrgUnit> </Affiliation> </Author> <Author> <DisplayName>Sanz, J</DisplayName> <Person id="rp03177" /> <Affiliation> <OrgUnit> </OrgUnit> </Affiliation> </Author> <Author> <DisplayName>Martinez-Diaz, RA</DisplayName> <Person id="rp03175" /> <Affiliation> <OrgUnit> </OrgUnit> </Affiliation> </Author> </Authors> <Editors> </Editors> <Publishers> <Publisher> <DisplayName>Parasitology Research</DisplayName> <OrgUnit /> </Publisher> </Publishers> <Keyword>Perú</Keyword> <Keyword>Biologia</Keyword> <Keyword>Farmacologia</Keyword> <Abstract>Extracts (34) from eight plant species of the Peruvian Amazonia currently used in traditional Peruvian medicine, mostly as antileishmanial remedies and also as painkiller, antiseptic, antipyretic, anti-inflamatory, antiflu, astringent, diuretic, antipoison, anticancerous, antiparasitic, insecticidal, or healing agents, have been tested for their antileishmanial, antitrypanosomal, and cytotoxic activity. Plant species were selected based on interviews conducted with residents of rural areas. The different plant parts were dried, powdered, and extracted by maceration with different solvents (hexane, chloroform, and 70% ethanol–water). These extracts were tested on promastigote forms of Leishmania infantum strain PB75, epimastigote forms of Trypanosoma cruzi strain Y, and the mammalian CHO cell line. Parasite viability and nonspecific cytotoxicity were analyzed by a modified MTT colorimetric assay method. The isolation and identification of pure compounds from selected extracts were performed by column chromatography, gas chromatography mass spectrometry (GC-MS; mixtures), spectroscopic techniques [MS, infrared (IR), ultraviolet (UV)], and mono and two-dimensional 1H and 13C nuclear magnetic resonance (NMR; COSY, HSQC, NOESY) experiments. Chondodendron tomentosum bark and Cedrela odorata were the most active extracts against Leishmania, while C. odorata and Aristoloquia pilosa were the most active against Trypanosoma, followed by Tabebuia serratifolia, Tradescantia zebrina, and Zamia ulei. Six compounds and two mixtures were isolated from Z. ulei [cycasin (1)], T. serratifolia {mixtures 1–2, and naphthoquinones 2-acetyl-4H,9H-naphtho[2,3-b]furan-4,9-dione (2) and 2-(1-hydroxyethyl)-4H,9H-naphtho[2,3-b]furan-4,9-dione (3)}, and C. tomentosum [chondrocurine (4); (S,S′)-12-O-methyl(+)-curine (5); and cycleanine (6)]. Four compounds and the two mixtures exhibited significant activity.</Abstract> <Access xmlns="http://purl.org/coar/access_right" > </Access> </Publication> -1
score 13.457506
Antileishmanial, antitrypanosomal, and cytotoxic screening of ethnopharmacologically selected Peruvian plants
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