A differential DNA methylome signature of pulmonary immune cells from individuals converting to latent tuberculosis infection
Descripción del Articulo
We would like to show our appreciation to the medical personnel at Instituto de Medicina Tropical Alexander von Humboldt, Universidad Peruana Cayetano Heredia, for assistance in sample collections and analysis of QuantiFERON® TB-Gold Plus test. We thank the Bioinformatics and Expression Analysis cor...
| Autores: | , , , , , , , , , , |
|---|---|
| Formato: | artículo |
| Fecha de Publicación: | 2021 |
| Institución: | Consejo Nacional de Ciencia Tecnología e Innovación |
| Repositorio: | CONCYTEC-Institucional |
| Lenguaje: | inglés |
| OAI Identifier: | oai:repositorio.concytec.gob.pe:20.500.12390/2955 |
| Enlace del recurso: | https://hdl.handle.net/20.500.12390/2955 https://doi.org/10.1038/s41598-021-98542-3 |
| Nivel de acceso: | acceso abierto |
| Materia: | tuberculosis infection epigenetic modifications https://purl.org/pe-repo/ocde/ford#3.04.03 |
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4689 |
| dc.title.none.fl_str_mv |
A differential DNA methylome signature of pulmonary immune cells from individuals converting to latent tuberculosis infection |
| title |
A differential DNA methylome signature of pulmonary immune cells from individuals converting to latent tuberculosis infection |
| spellingShingle |
A differential DNA methylome signature of pulmonary immune cells from individuals converting to latent tuberculosis infection Karlsson L. tuberculosis infection epigenetic modifications https://purl.org/pe-repo/ocde/ford#3.04.03 |
| title_short |
A differential DNA methylome signature of pulmonary immune cells from individuals converting to latent tuberculosis infection |
| title_full |
A differential DNA methylome signature of pulmonary immune cells from individuals converting to latent tuberculosis infection |
| title_fullStr |
A differential DNA methylome signature of pulmonary immune cells from individuals converting to latent tuberculosis infection |
| title_full_unstemmed |
A differential DNA methylome signature of pulmonary immune cells from individuals converting to latent tuberculosis infection |
| title_sort |
A differential DNA methylome signature of pulmonary immune cells from individuals converting to latent tuberculosis infection |
| author |
Karlsson L. |
| author_facet |
Karlsson L. Das J. Nilsson M. Tyrén A. Pehrson I. Idh N. Sayyab S. Paues J. Ugarte-Gil C. Méndez-Aranda M. Lerm M. |
| author_role |
author |
| author2 |
Das J. Nilsson M. Tyrén A. Pehrson I. Idh N. Sayyab S. Paues J. Ugarte-Gil C. Méndez-Aranda M. Lerm M. |
| author2_role |
author author author author author author author author author author |
| dc.contributor.author.fl_str_mv |
Karlsson L. Das J. Nilsson M. Tyrén A. Pehrson I. Idh N. Sayyab S. Paues J. Ugarte-Gil C. Méndez-Aranda M. Lerm M. |
| dc.subject.none.fl_str_mv |
tuberculosis infection |
| topic |
tuberculosis infection epigenetic modifications https://purl.org/pe-repo/ocde/ford#3.04.03 |
| dc.subject.es_PE.fl_str_mv |
epigenetic modifications |
| dc.subject.ocde.none.fl_str_mv |
https://purl.org/pe-repo/ocde/ford#3.04.03 |
| description |
We would like to show our appreciation to the medical personnel at Instituto de Medicina Tropical Alexander von Humboldt, Universidad Peruana Cayetano Heredia, for assistance in sample collections and analysis of QuantiFERON® TB-Gold Plus test. We thank the Bioinformatics and Expression Analysis core facility (BEA) at Karolinska Institute that preformed the sequencing analysis. We thank the Swedish National Infrastructure for Computing (SNIC) at National Supercomputing Centre (NSC), Linköping University for the computing systems enabling the data handling, partially funded by the Swedish Research Council through grant agreement No. 2018-05973. The work was supported by grants from the Swedish Research Council No. 2018-04246 and the Consejo Nacional de Ciencia, Tecnología e Innovación Tecnológica CONCYTEC and Cienciactiva No. 106-2018-FONDECYT. J.D is a postdoctoral fellow supported through the Medical Infection and Inflammation Center (MIIC) at Linköping University. |
| publishDate |
2021 |
| dc.date.accessioned.none.fl_str_mv |
2024-05-30T23:13:38Z |
| dc.date.available.none.fl_str_mv |
2024-05-30T23:13:38Z |
| dc.date.issued.fl_str_mv |
2021 |
| dc.type.none.fl_str_mv |
info:eu-repo/semantics/article |
| format |
article |
| dc.identifier.uri.none.fl_str_mv |
https://hdl.handle.net/20.500.12390/2955 |
| dc.identifier.doi.none.fl_str_mv |
https://doi.org/10.1038/s41598-021-98542-3 |
| dc.identifier.scopus.none.fl_str_mv |
2-s2.0-85116393607 |
| url |
https://hdl.handle.net/20.500.12390/2955 https://doi.org/10.1038/s41598-021-98542-3 |
| identifier_str_mv |
2-s2.0-85116393607 |
| dc.language.iso.none.fl_str_mv |
eng |
| language |
eng |
| dc.relation.ispartof.none.fl_str_mv |
Scientific Reports |
| dc.rights.none.fl_str_mv |
info:eu-repo/semantics/openAccess |
| dc.rights.uri.none.fl_str_mv |
https://creativecommons.org/licenses/by-nc-nd/4.0/ |
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openAccess |
| rights_invalid_str_mv |
https://creativecommons.org/licenses/by-nc-nd/4.0/ |
| dc.publisher.none.fl_str_mv |
Nature Research |
| publisher.none.fl_str_mv |
Nature Research |
| dc.source.none.fl_str_mv |
reponame:CONCYTEC-Institucional instname:Consejo Nacional de Ciencia Tecnología e Innovación instacron:CONCYTEC |
| instname_str |
Consejo Nacional de Ciencia Tecnología e Innovación |
| instacron_str |
CONCYTEC |
| institution |
CONCYTEC |
| reponame_str |
CONCYTEC-Institucional |
| collection |
CONCYTEC-Institucional |
| repository.name.fl_str_mv |
Repositorio Institucional CONCYTEC |
| repository.mail.fl_str_mv |
repositorio@concytec.gob.pe |
| _version_ |
1844883053541851136 |
| spelling |
Publicationrp08366600rp08360600rp08365600rp08369600rp08361600rp08363600rp08367600rp08368600rp06758600rp08362600rp08364600Karlsson L.Das J.Nilsson M.Tyrén A.Pehrson I.Idh N.Sayyab S.Paues J.Ugarte-Gil C.Méndez-Aranda M.Lerm M.2024-05-30T23:13:38Z2024-05-30T23:13:38Z2021https://hdl.handle.net/20.500.12390/2955https://doi.org/10.1038/s41598-021-98542-32-s2.0-85116393607We would like to show our appreciation to the medical personnel at Instituto de Medicina Tropical Alexander von Humboldt, Universidad Peruana Cayetano Heredia, for assistance in sample collections and analysis of QuantiFERON® TB-Gold Plus test. We thank the Bioinformatics and Expression Analysis core facility (BEA) at Karolinska Institute that preformed the sequencing analysis. We thank the Swedish National Infrastructure for Computing (SNIC) at National Supercomputing Centre (NSC), Linköping University for the computing systems enabling the data handling, partially funded by the Swedish Research Council through grant agreement No. 2018-05973. The work was supported by grants from the Swedish Research Council No. 2018-04246 and the Consejo Nacional de Ciencia, Tecnología e Innovación Tecnológica CONCYTEC and Cienciactiva No. 106-2018-FONDECYT. J.D is a postdoctoral fellow supported through the Medical Infection and Inflammation Center (MIIC) at Linköping University.Tuberculosis (TB), caused by Mycobacterium tuberculosis, spreads via aerosols and the first encounter with the immune system is with the pulmonary-resident immune cells. The role of epigenetic regulations in the immune cells is emerging and we have previously shown that macrophages capacity to kill M. tuberculosis is reflected in the DNA methylome. The aim of this study was to investigate epigenetic modifications in alveolar macrophages and T cells in a cohort of medical students with an increased risk of TB exposure, longitudinally. DNA methylome analysis revealed that a unique DNA methylation profile was present in healthy subjects who later developed latent TB during the study. The profile was reflected in a different overall DNA methylation distribution as well as a distinct set of differentially methylated genes (DMGs). The DMGs were over-represented in pathways related to metabolic reprogramming of macrophages and T cell migration and IFN-? production, pathways previously reported important in TB control. In conclusion, we identified a unique DNA methylation signature in individuals, with no peripheral immune response to M. tuberculosis antigen who later developed latent TB. Together the study suggests that the DNA methylation status of pulmonary immune cells can reveal who will develop latent TB infection. © 2021, The Author(s).Consejo Nacional de Ciencia, Tecnología e Innovación Tecnológica - ConcytecengNature ResearchScientific Reportsinfo:eu-repo/semantics/openAccesshttps://creativecommons.org/licenses/by-nc-nd/4.0/tuberculosis infectionepigenetic modifications-1https://purl.org/pe-repo/ocde/ford#3.04.03-1A differential DNA methylome signature of pulmonary immune cells from individuals converting to latent tuberculosis infectioninfo:eu-repo/semantics/articlereponame:CONCYTEC-Institucionalinstname:Consejo Nacional de Ciencia Tecnología e Innovacióninstacron:CONCYTEC20.500.12390/2955oai:repositorio.concytec.gob.pe:20.500.12390/29552024-05-30 16:12:28.548https://creativecommons.org/licenses/by-nc-nd/4.0/info:eu-repo/semantics/openAccesshttp://purl.org/coar/access_right/c_14cbinfo:eu-repo/semantics/closedAccessmetadata only accesshttps://repositorio.concytec.gob.peRepositorio Institucional CONCYTECrepositorio@concytec.gob.pe#PLACEHOLDER_PARENT_METADATA_VALUE##PLACEHOLDER_PARENT_METADATA_VALUE##PLACEHOLDER_PARENT_METADATA_VALUE##PLACEHOLDER_PARENT_METADATA_VALUE##PLACEHOLDER_PARENT_METADATA_VALUE##PLACEHOLDER_PARENT_METADATA_VALUE##PLACEHOLDER_PARENT_METADATA_VALUE##PLACEHOLDER_PARENT_METADATA_VALUE##PLACEHOLDER_PARENT_METADATA_VALUE##PLACEHOLDER_PARENT_METADATA_VALUE##PLACEHOLDER_PARENT_METADATA_VALUE#<Publication xmlns="https://www.openaire.eu/cerif-profile/1.1/" id="09e65ec2-c59c-4164-8ff6-80245e415b20"> <Type xmlns="https://www.openaire.eu/cerif-profile/vocab/COAR_Publication_Types">http://purl.org/coar/resource_type/c_1843</Type> <Language>eng</Language> <Title>A differential DNA methylome signature of pulmonary immune cells from individuals converting to latent tuberculosis infection</Title> <PublishedIn> <Publication> <Title>Scientific Reports</Title> </Publication> </PublishedIn> <PublicationDate>2021</PublicationDate> <DOI>https://doi.org/10.1038/s41598-021-98542-3</DOI> <SCP-Number>2-s2.0-85116393607</SCP-Number> <Authors> <Author> <DisplayName>Karlsson L.</DisplayName> <Person id="rp08366" /> <Affiliation> <OrgUnit> </OrgUnit> </Affiliation> </Author> <Author> <DisplayName>Das J.</DisplayName> <Person id="rp08360" /> <Affiliation> <OrgUnit> </OrgUnit> </Affiliation> </Author> <Author> <DisplayName>Nilsson M.</DisplayName> <Person id="rp08365" /> <Affiliation> <OrgUnit> </OrgUnit> </Affiliation> </Author> <Author> <DisplayName>Tyrén A.</DisplayName> <Person id="rp08369" /> <Affiliation> <OrgUnit> </OrgUnit> </Affiliation> </Author> <Author> <DisplayName>Pehrson I.</DisplayName> <Person id="rp08361" /> <Affiliation> <OrgUnit> </OrgUnit> </Affiliation> </Author> <Author> <DisplayName>Idh N.</DisplayName> <Person id="rp08363" /> <Affiliation> <OrgUnit> </OrgUnit> </Affiliation> </Author> <Author> <DisplayName>Sayyab S.</DisplayName> <Person id="rp08367" /> <Affiliation> <OrgUnit> </OrgUnit> </Affiliation> </Author> <Author> <DisplayName>Paues J.</DisplayName> <Person id="rp08368" /> <Affiliation> <OrgUnit> </OrgUnit> </Affiliation> </Author> <Author> <DisplayName>Ugarte-Gil C.</DisplayName> <Person id="rp06758" /> <Affiliation> <OrgUnit> </OrgUnit> </Affiliation> </Author> <Author> <DisplayName>Méndez-Aranda M.</DisplayName> <Person id="rp08362" /> <Affiliation> <OrgUnit> </OrgUnit> </Affiliation> </Author> <Author> <DisplayName>Lerm M.</DisplayName> <Person id="rp08364" /> <Affiliation> <OrgUnit> </OrgUnit> </Affiliation> </Author> </Authors> <Editors> </Editors> <Publishers> <Publisher> <DisplayName>Nature Research</DisplayName> <OrgUnit /> </Publisher> </Publishers> <License>https://creativecommons.org/licenses/by-nc-nd/4.0/</License> <Keyword>tuberculosis infection</Keyword> <Keyword>epigenetic modifications</Keyword> <Abstract>Tuberculosis (TB), caused by Mycobacterium tuberculosis, spreads via aerosols and the first encounter with the immune system is with the pulmonary-resident immune cells. The role of epigenetic regulations in the immune cells is emerging and we have previously shown that macrophages capacity to kill M. tuberculosis is reflected in the DNA methylome. The aim of this study was to investigate epigenetic modifications in alveolar macrophages and T cells in a cohort of medical students with an increased risk of TB exposure, longitudinally. DNA methylome analysis revealed that a unique DNA methylation profile was present in healthy subjects who later developed latent TB during the study. The profile was reflected in a different overall DNA methylation distribution as well as a distinct set of differentially methylated genes (DMGs). The DMGs were over-represented in pathways related to metabolic reprogramming of macrophages and T cell migration and IFN-? production, pathways previously reported important in TB control. In conclusion, we identified a unique DNA methylation signature in individuals, with no peripheral immune response to M. tuberculosis antigen who later developed latent TB. Together the study suggests that the DNA methylation status of pulmonary immune cells can reveal who will develop latent TB infection. © 2021, The Author(s).</Abstract> <Access xmlns="http://purl.org/coar/access_right" > </Access> </Publication> -1 |
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Nota importante:
La información contenida en este registro es de entera responsabilidad de la institución que gestiona el repositorio institucional donde esta contenido este documento o set de datos. El CONCYTEC no se hace responsable por los contenidos (publicaciones y/o datos) accesibles a través del Repositorio Nacional Digital de Ciencia, Tecnología e Innovación de Acceso Abierto (ALICIA).
La información contenida en este registro es de entera responsabilidad de la institución que gestiona el repositorio institucional donde esta contenido este documento o set de datos. El CONCYTEC no se hace responsable por los contenidos (publicaciones y/o datos) accesibles a través del Repositorio Nacional Digital de Ciencia, Tecnología e Innovación de Acceso Abierto (ALICIA).
