Outcomes following severe hand foot and mouth disease: A systematic review and meta-analysis

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HRvD and SS were funded by the Wellcome Trust of Great Britain ( 089276/Z/09/Z and 106680/Z/14/Z ) and a Li Ka Shing Foundation–University of Oxford Global Health Program strategic award ( LG17 ). JCBA has been awarded a doctoral scholarship by CIENCIACTIVA, an initiative of the Peruvian National Co...

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Autores: Jones E., Pillay T.D., Liu F., Luo L., Bazo-Alvarez J.C., Yuan C., Zhao S., Chen Q., Li Y., Liao Q., Yu H., Rogier van Doorn H., Sabanathan S.
Formato: revisión
Fecha de Publicación:2018
Institución:Consejo Nacional de Ciencia Tecnología e Innovación
Repositorio:CONCYTEC-Institucional
Lenguaje:inglés
OAI Identifier:oai:repositorio.concytec.gob.pe:20.500.12390/728
Enlace del recurso:https://hdl.handle.net/20.500.12390/728
https://doi.org/10.1016/j.ejpn.2018.04.007
Nivel de acceso:acceso abierto
Materia:Embase
Acute disease
ataxia
Cochrane Library
disease severity
dysphagia
https://purl.org/pe-repo/ocde/ford#3.01.00
id CONC_71acf521e9bdd282e1727cd3a020891a
oai_identifier_str oai:repositorio.concytec.gob.pe:20.500.12390/728
network_acronym_str CONC
network_name_str CONCYTEC-Institucional
repository_id_str 4689
dc.title.none.fl_str_mv Outcomes following severe hand foot and mouth disease: A systematic review and meta-analysis
title Outcomes following severe hand foot and mouth disease: A systematic review and meta-analysis
spellingShingle Outcomes following severe hand foot and mouth disease: A systematic review and meta-analysis
Jones E.
Embase
Acute disease
ataxia
Cochrane Library
disease severity
dysphagia
https://purl.org/pe-repo/ocde/ford#3.01.00
title_short Outcomes following severe hand foot and mouth disease: A systematic review and meta-analysis
title_full Outcomes following severe hand foot and mouth disease: A systematic review and meta-analysis
title_fullStr Outcomes following severe hand foot and mouth disease: A systematic review and meta-analysis
title_full_unstemmed Outcomes following severe hand foot and mouth disease: A systematic review and meta-analysis
title_sort Outcomes following severe hand foot and mouth disease: A systematic review and meta-analysis
author Jones E.
author_facet Jones E.
Pillay T.D.
Liu F.
Luo L.
Bazo-Alvarez J.C.
Yuan C.
Zhao S.
Chen Q.
Li Y.
Liao Q.
Yu H.
Rogier van Doorn H.
Sabanathan S.
author_role author
author2 Pillay T.D.
Liu F.
Luo L.
Bazo-Alvarez J.C.
Yuan C.
Zhao S.
Chen Q.
Li Y.
Liao Q.
Yu H.
Rogier van Doorn H.
Sabanathan S.
author2_role author
author
author
author
author
author
author
author
author
author
author
author
dc.contributor.author.fl_str_mv Jones E.
Pillay T.D.
Liu F.
Luo L.
Bazo-Alvarez J.C.
Yuan C.
Zhao S.
Chen Q.
Li Y.
Liao Q.
Yu H.
Rogier van Doorn H.
Sabanathan S.
dc.subject.none.fl_str_mv Embase
topic Embase
Acute disease
ataxia
Cochrane Library
disease severity
dysphagia
https://purl.org/pe-repo/ocde/ford#3.01.00
dc.subject.es_PE.fl_str_mv Acute disease
ataxia
Cochrane Library
disease severity
dysphagia
dc.subject.ocde.none.fl_str_mv https://purl.org/pe-repo/ocde/ford#3.01.00
description HRvD and SS were funded by the Wellcome Trust of Great Britain ( 089276/Z/09/Z and 106680/Z/14/Z ) and a Li Ka Shing Foundation–University of Oxford Global Health Program strategic award ( LG17 ). JCBA has been awarded a doctoral scholarship by CIENCIACTIVA, an initiative of the Peruvian National Council of Science, Technology and Technological Innovation (CONCYTEC); grant contract number 231-2015-FONDECYT. HY was supported by the National Science Fund for Distinguished Young Scholars ( No.81525023 ), the National Natural Science Foundation of China ( No. 81473031 ), the Li Ka Shing Oxford Global Health Programme ( No.B9RST00-B900.57 ).
publishDate 2018
dc.date.accessioned.none.fl_str_mv 2024-05-30T23:13:38Z
dc.date.available.none.fl_str_mv 2024-05-30T23:13:38Z
dc.date.issued.fl_str_mv 2018
dc.type.none.fl_str_mv info:eu-repo/semantics/review
format review
dc.identifier.uri.none.fl_str_mv https://hdl.handle.net/20.500.12390/728
dc.identifier.doi.none.fl_str_mv https://doi.org/10.1016/j.ejpn.2018.04.007
dc.identifier.scopus.none.fl_str_mv 2-s2.0-85047211684
url https://hdl.handle.net/20.500.12390/728
https://doi.org/10.1016/j.ejpn.2018.04.007
identifier_str_mv 2-s2.0-85047211684
dc.language.iso.none.fl_str_mv eng
language eng
dc.relation.ispartof.none.fl_str_mv European Journal of Paediatric Neurology
dc.rights.none.fl_str_mv info:eu-repo/semantics/openAccess
dc.rights.uri.none.fl_str_mv https://creativecommons.org/licenses/by/4.0/
eu_rights_str_mv openAccess
rights_invalid_str_mv https://creativecommons.org/licenses/by/4.0/
dc.publisher.none.fl_str_mv W.B. Saunders Ltd
publisher.none.fl_str_mv W.B. Saunders Ltd
dc.source.none.fl_str_mv reponame:CONCYTEC-Institucional
instname:Consejo Nacional de Ciencia Tecnología e Innovación
instacron:CONCYTEC
instname_str Consejo Nacional de Ciencia Tecnología e Innovación
instacron_str CONCYTEC
institution CONCYTEC
reponame_str CONCYTEC-Institucional
collection CONCYTEC-Institucional
repository.name.fl_str_mv Repositorio Institucional CONCYTEC
repository.mail.fl_str_mv repositorio@concytec.gob.pe
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spelling Publicationrp01822600rp01823600rp01826600rp01828600rp00647500rp01830600rp01821600rp01824600rp01583500rp01829600rp01825600rp01831600rp01827600Jones E.Pillay T.D.Liu F.Luo L.Bazo-Alvarez J.C.Yuan C.Zhao S.Chen Q.Li Y.Liao Q.Yu H.Rogier van Doorn H.Sabanathan S.2024-05-30T23:13:38Z2024-05-30T23:13:38Z2018https://hdl.handle.net/20.500.12390/728https://doi.org/10.1016/j.ejpn.2018.04.0072-s2.0-85047211684HRvD and SS were funded by the Wellcome Trust of Great Britain ( 089276/Z/09/Z and 106680/Z/14/Z ) and a Li Ka Shing Foundation–University of Oxford Global Health Program strategic award ( LG17 ). JCBA has been awarded a doctoral scholarship by CIENCIACTIVA, an initiative of the Peruvian National Council of Science, Technology and Technological Innovation (CONCYTEC); grant contract number 231-2015-FONDECYT. HY was supported by the National Science Fund for Distinguished Young Scholars ( No.81525023 ), the National Natural Science Foundation of China ( No. 81473031 ), the Li Ka Shing Oxford Global Health Programme ( No.B9RST00-B900.57 ).Background. Hand, foot and mouth disease (HFMD) caused by enterovirus A71 (EV-A71) is associated with acute neurological disease in children. This study aimed to estimate the burden of long-term sequelae and death following severe HFMD. Methods. This systematic review and meta-analysis pooled all reports from English and Chinese databases including MEDLINE and Wangfang on outbreaks of clinically diagnosed HFMD and/or laboratory-confirmed EV-A71 with at least 7 days' follow-up published between 1st January 1966 and 19th October 2015. Methods.This systematic review and meta-analysis pooled all reports from English and Chinese databases including MEDLINE and Wangfang on outbreaks of clinically diagnosed HFMD and/or laboratory-confirmed EV-A71 with at least 7 days' follow-up published between 1st January 1966 and 19th October 2015.Two independent reviewers assessed the literature.We used a random effects meta-analysis to estimate cumulative incidence of neurological sequelae or death. Studies were assessed for methodological and reporting quality. Findings. 43 studies were included in the review, and 599 children from 9 studies were included in the primary analysis. Estimated cumulative incidence of death or neurological sequelae at maximum follow up was 19.8% (95% CI:10.2%, 31.3%). Heterogeneity (Iˆ2) was 88.57%, partly accounted for by year of data collection and reporting quality of studies. Incidence by acute disease severity was 0.00% (0.00, 0.00) for grade IIa; 17.0% (7.9, 28.2) for grade IIb/III; 81.6% (65.1, 94.5) for grade IV (p = 0.00) disease.Consejo Nacional de Ciencia, Tecnología e Innovación Tecnológica - ConcytecengW.B. Saunders LtdEuropean Journal of Paediatric Neurologyinfo:eu-repo/semantics/openAccesshttps://creativecommons.org/licenses/by/4.0/EmbaseAcute disease-1ataxia-1Cochrane Library-1disease severity-1dysphagia-1https://purl.org/pe-repo/ocde/ford#3.01.00-1Outcomes following severe hand foot and mouth disease: A systematic review and meta-analysisinfo:eu-repo/semantics/reviewreponame:CONCYTEC-Institucionalinstname:Consejo Nacional de Ciencia Tecnología e Innovacióninstacron:CONCYTEC#PLACEHOLDER_PARENT_METADATA_VALUE##PLACEHOLDER_PARENT_METADATA_VALUE##PLACEHOLDER_PARENT_METADATA_VALUE##PLACEHOLDER_PARENT_METADATA_VALUE##PLACEHOLDER_PARENT_METADATA_VALUE##PLACEHOLDER_PARENT_METADATA_VALUE##PLACEHOLDER_PARENT_METADATA_VALUE##PLACEHOLDER_PARENT_METADATA_VALUE##PLACEHOLDER_PARENT_METADATA_VALUE##PLACEHOLDER_PARENT_METADATA_VALUE##PLACEHOLDER_PARENT_METADATA_VALUE##PLACEHOLDER_PARENT_METADATA_VALUE##PLACEHOLDER_PARENT_METADATA_VALUE#20.500.12390/728oai:repositorio.concytec.gob.pe:20.500.12390/7282024-05-30 15:22:44.554https://creativecommons.org/licenses/by/4.0/info:eu-repo/semantics/openAccesshttp://purl.org/coar/access_right/c_14cbinfo:eu-repo/semantics/closedAccessmetadata only accesshttps://repositorio.concytec.gob.peRepositorio Institucional CONCYTECrepositorio@concytec.gob.pe#PLACEHOLDER_PARENT_METADATA_VALUE##PLACEHOLDER_PARENT_METADATA_VALUE##PLACEHOLDER_PARENT_METADATA_VALUE##PLACEHOLDER_PARENT_METADATA_VALUE##PLACEHOLDER_PARENT_METADATA_VALUE##PLACEHOLDER_PARENT_METADATA_VALUE##PLACEHOLDER_PARENT_METADATA_VALUE##PLACEHOLDER_PARENT_METADATA_VALUE##PLACEHOLDER_PARENT_METADATA_VALUE##PLACEHOLDER_PARENT_METADATA_VALUE##PLACEHOLDER_PARENT_METADATA_VALUE##PLACEHOLDER_PARENT_METADATA_VALUE##PLACEHOLDER_PARENT_METADATA_VALUE#<Publication xmlns="https://www.openaire.eu/cerif-profile/1.1/" id="f4eea3fa-dbca-418f-8c60-0e6749ff180b"> <Type xmlns="https://www.openaire.eu/cerif-profile/vocab/COAR_Publication_Types">http://purl.org/coar/resource_type/c_1843</Type> <Language>eng</Language> <Title>Outcomes following severe hand foot and mouth disease: A systematic review and meta-analysis</Title> <PublishedIn> <Publication> <Title>European Journal of Paediatric Neurology</Title> </Publication> </PublishedIn> <PublicationDate>2018</PublicationDate> <DOI>https://doi.org/10.1016/j.ejpn.2018.04.007</DOI> <SCP-Number>2-s2.0-85047211684</SCP-Number> <Authors> <Author> <DisplayName>Jones E.</DisplayName> <Person id="rp01822" /> <Affiliation> <OrgUnit> </OrgUnit> </Affiliation> </Author> <Author> <DisplayName>Pillay T.D.</DisplayName> <Person id="rp01823" /> <Affiliation> <OrgUnit> </OrgUnit> </Affiliation> </Author> <Author> <DisplayName>Liu F.</DisplayName> <Person id="rp01826" /> <Affiliation> <OrgUnit> </OrgUnit> </Affiliation> </Author> <Author> <DisplayName>Luo L.</DisplayName> <Person id="rp01828" /> <Affiliation> <OrgUnit> </OrgUnit> </Affiliation> </Author> <Author> <DisplayName>Bazo-Alvarez J.C.</DisplayName> <Person id="rp00647" /> <Affiliation> <OrgUnit> </OrgUnit> </Affiliation> </Author> <Author> <DisplayName>Yuan C.</DisplayName> <Person id="rp01830" /> <Affiliation> <OrgUnit> </OrgUnit> </Affiliation> </Author> <Author> <DisplayName>Zhao S.</DisplayName> <Person id="rp01821" /> <Affiliation> <OrgUnit> </OrgUnit> </Affiliation> </Author> <Author> <DisplayName>Chen Q.</DisplayName> <Person id="rp01824" /> <Affiliation> <OrgUnit> </OrgUnit> </Affiliation> </Author> <Author> <DisplayName>Li Y.</DisplayName> <Person id="rp01583" /> <Affiliation> <OrgUnit> </OrgUnit> </Affiliation> </Author> <Author> <DisplayName>Liao Q.</DisplayName> <Person id="rp01829" /> <Affiliation> <OrgUnit> </OrgUnit> </Affiliation> </Author> <Author> <DisplayName>Yu H.</DisplayName> <Person id="rp01825" /> <Affiliation> <OrgUnit> </OrgUnit> </Affiliation> </Author> <Author> <DisplayName>Rogier van Doorn H.</DisplayName> <Person id="rp01831" /> <Affiliation> <OrgUnit> </OrgUnit> </Affiliation> </Author> <Author> <DisplayName>Sabanathan S.</DisplayName> <Person id="rp01827" /> <Affiliation> <OrgUnit> </OrgUnit> </Affiliation> </Author> </Authors> <Editors> </Editors> <Publishers> <Publisher> <DisplayName>W.B. Saunders Ltd</DisplayName> <OrgUnit /> </Publisher> </Publishers> <License>https://creativecommons.org/licenses/by/4.0/</License> <Keyword>Embase</Keyword> <Keyword>Acute disease</Keyword> <Keyword>ataxia</Keyword> <Keyword>Cochrane Library</Keyword> <Keyword>disease severity</Keyword> <Keyword>dysphagia</Keyword> <Abstract>Background. Hand, foot and mouth disease (HFMD) caused by enterovirus A71 (EV-A71) is associated with acute neurological disease in children. This study aimed to estimate the burden of long-term sequelae and death following severe HFMD. Methods. This systematic review and meta-analysis pooled all reports from English and Chinese databases including MEDLINE and Wangfang on outbreaks of clinically diagnosed HFMD and/or laboratory-confirmed EV-A71 with at least 7 days&apos; follow-up published between 1st January 1966 and 19th October 2015. Methods.This systematic review and meta-analysis pooled all reports from English and Chinese databases including MEDLINE and Wangfang on outbreaks of clinically diagnosed HFMD and/or laboratory-confirmed EV-A71 with at least 7 days&apos; follow-up published between 1st January 1966 and 19th October 2015.Two independent reviewers assessed the literature.We used a random effects meta-analysis to estimate cumulative incidence of neurological sequelae or death. Studies were assessed for methodological and reporting quality. Findings. 43 studies were included in the review, and 599 children from 9 studies were included in the primary analysis. Estimated cumulative incidence of death or neurological sequelae at maximum follow up was 19.8% (95% CI:10.2%, 31.3%). Heterogeneity (Iˆ2) was 88.57%, partly accounted for by year of data collection and reporting quality of studies. Incidence by acute disease severity was 0.00% (0.00, 0.00) for grade IIa; 17.0% (7.9, 28.2) for grade IIb/III; 81.6% (65.1, 94.5) for grade IV (p = 0.00) disease.</Abstract> <Access xmlns="http://purl.org/coar/access_right" > </Access> </Publication> -1
score 13.4491415
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