Influence of the soluble-insoluble ratios of cyclodextrins polymers on the viscoelastic properties of injectable chitosan-based hydrogels for biomedical application
Descripción del Articulo
This research was funded by FONDECYT–CONCYTEC (grant contract number 274-2015-FONDECYT).
| Autores: | , , , , , |
|---|---|
| Formato: | artículo |
| Fecha de Publicación: | 2019 |
| Institución: | Consejo Nacional de Ciencia Tecnología e Innovación |
| Repositorio: | CONCYTEC-Institucional |
| Lenguaje: | inglés |
| OAI Identifier: | oai:repositorio.concytec.gob.pe:20.500.12390/659 |
| Enlace del recurso: | https://hdl.handle.net/20.500.12390/659 https://doi.org/10.3390/polym11020214 |
| Nivel de acceso: | acceso abierto |
| Materia: | Watersoluble polymers Chitosan Cyclodextrins Functional polymers Medical applications Polyelectrolytes Shear flow Shear thinning Stability Viscoelasticity Injectable hydrogels Insoluble polymers Self-healing Viscoelastic properties Hydrogels https://purl.org/pe-repo/ocde/ford#3.00.00 |
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oai:repositorio.concytec.gob.pe:20.500.12390/659 |
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CONC |
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CONCYTEC-Institucional |
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4689 |
| dc.title.none.fl_str_mv |
Influence of the soluble-insoluble ratios of cyclodextrins polymers on the viscoelastic properties of injectable chitosan-based hydrogels for biomedical application |
| title |
Influence of the soluble-insoluble ratios of cyclodextrins polymers on the viscoelastic properties of injectable chitosan-based hydrogels for biomedical application |
| spellingShingle |
Influence of the soluble-insoluble ratios of cyclodextrins polymers on the viscoelastic properties of injectable chitosan-based hydrogels for biomedical application Palomino-Durand C. Watersoluble polymers Chitosan Cyclodextrins Functional polymers Medical applications Polyelectrolytes Shear flow Shear thinning Stability Viscoelasticity Injectable hydrogels Insoluble polymers Self-healing Viscoelastic properties Hydrogels https://purl.org/pe-repo/ocde/ford#3.00.00 |
| title_short |
Influence of the soluble-insoluble ratios of cyclodextrins polymers on the viscoelastic properties of injectable chitosan-based hydrogels for biomedical application |
| title_full |
Influence of the soluble-insoluble ratios of cyclodextrins polymers on the viscoelastic properties of injectable chitosan-based hydrogels for biomedical application |
| title_fullStr |
Influence of the soluble-insoluble ratios of cyclodextrins polymers on the viscoelastic properties of injectable chitosan-based hydrogels for biomedical application |
| title_full_unstemmed |
Influence of the soluble-insoluble ratios of cyclodextrins polymers on the viscoelastic properties of injectable chitosan-based hydrogels for biomedical application |
| title_sort |
Influence of the soluble-insoluble ratios of cyclodextrins polymers on the viscoelastic properties of injectable chitosan-based hydrogels for biomedical application |
| author |
Palomino-Durand C. |
| author_facet |
Palomino-Durand C. Lopez M. Cazaux F. Martel B. Blanchemain N. Chai F. |
| author_role |
author |
| author2 |
Lopez M. Cazaux F. Martel B. Blanchemain N. Chai F. |
| author2_role |
author author author author author |
| dc.contributor.author.fl_str_mv |
Palomino-Durand C. Lopez M. Cazaux F. Martel B. Blanchemain N. Chai F. |
| dc.subject.none.fl_str_mv |
Watersoluble polymers |
| topic |
Watersoluble polymers Chitosan Cyclodextrins Functional polymers Medical applications Polyelectrolytes Shear flow Shear thinning Stability Viscoelasticity Injectable hydrogels Insoluble polymers Self-healing Viscoelastic properties Hydrogels https://purl.org/pe-repo/ocde/ford#3.00.00 |
| dc.subject.es_PE.fl_str_mv |
Chitosan Cyclodextrins Functional polymers Medical applications Polyelectrolytes Shear flow Shear thinning Stability Viscoelasticity Injectable hydrogels Insoluble polymers Self-healing Viscoelastic properties Hydrogels |
| dc.subject.ocde.none.fl_str_mv |
https://purl.org/pe-repo/ocde/ford#3.00.00 |
| description |
This research was funded by FONDECYT–CONCYTEC (grant contract number 274-2015-FONDECYT). |
| publishDate |
2019 |
| dc.date.accessioned.none.fl_str_mv |
2024-05-30T23:13:38Z |
| dc.date.available.none.fl_str_mv |
2024-05-30T23:13:38Z |
| dc.date.issued.fl_str_mv |
2019 |
| dc.type.none.fl_str_mv |
info:eu-repo/semantics/article |
| format |
article |
| dc.identifier.uri.none.fl_str_mv |
https://hdl.handle.net/20.500.12390/659 |
| dc.identifier.doi.none.fl_str_mv |
https://doi.org/10.3390/polym11020214 |
| dc.identifier.scopus.none.fl_str_mv |
2-s2.0-85060655566 |
| url |
https://hdl.handle.net/20.500.12390/659 https://doi.org/10.3390/polym11020214 |
| identifier_str_mv |
2-s2.0-85060655566 |
| dc.language.iso.none.fl_str_mv |
eng |
| language |
eng |
| dc.relation.ispartof.none.fl_str_mv |
Polymers |
| dc.rights.none.fl_str_mv |
info:eu-repo/semantics/openAccess |
| dc.rights.uri.none.fl_str_mv |
https://creativecommons.org/licenses/by/4.0/ |
| eu_rights_str_mv |
openAccess |
| rights_invalid_str_mv |
https://creativecommons.org/licenses/by/4.0/ |
| dc.publisher.none.fl_str_mv |
MDPI AG |
| publisher.none.fl_str_mv |
MDPI AG |
| dc.source.none.fl_str_mv |
reponame:CONCYTEC-Institucional instname:Consejo Nacional de Ciencia Tecnología e Innovación instacron:CONCYTEC |
| instname_str |
Consejo Nacional de Ciencia Tecnología e Innovación |
| instacron_str |
CONCYTEC |
| institution |
CONCYTEC |
| reponame_str |
CONCYTEC-Institucional |
| collection |
CONCYTEC-Institucional |
| repository.name.fl_str_mv |
Repositorio Institucional CONCYTEC |
| repository.mail.fl_str_mv |
repositorio@concytec.gob.pe |
| _version_ |
1844883020599787520 |
| spelling |
Publicationrp01471600rp00741500rp01472600rp01189500rp01193500rp01187500Palomino-Durand C.Lopez M.Cazaux F.Martel B.Blanchemain N.Chai F.2024-05-30T23:13:38Z2024-05-30T23:13:38Z2019https://hdl.handle.net/20.500.12390/659https://doi.org/10.3390/polym110202142-s2.0-85060655566This research was funded by FONDECYT–CONCYTEC (grant contract number 274-2015-FONDECYT).Injectable pre-formed physical hydrogels provide many advantages for biomedical applications. Polyelectrolyte complexes (PEC) formed between cationic chitosan (CHT) and anionic polymers of cyclodextrin (PCD) render a hydrogel of great interest. Given the difference between water-soluble (PCDs) and water-insoluble PCD (PCDi) in the extension of polymerization, the present study aims to explore their impact on the formation and properties of CHT/PCD hydrogel obtained from the variable ratios of PCDi and PCDs in the formulation. Hydrogels CHT/PCDi/PCDs at weight ratios of 3:0:3, 3:1.5:1.5, and 3:3:0 were elaborated in a double⁻syringe system. The chemical composition, microstructure, viscoelastic properties, injectability, and structural integrity of the hydrogels were investigated. The cytotoxicity of the hydrogel was also evaluated by indirect contact with pre-osteoblast cells. Despite having similar shear⁻thinning and self-healing behaviors, the three hydrogels showed a marked difference in their rheological characteristics, injectability, structural stability, etc., depending on their PCDi and PCDs contents. Among the three, all the best above-mentioned properties, in addition to a high cytocompatibility, were found in the hydrogel 3:1.5:1.5. For the first time, we gained a deeper understanding of the role of the PCDi/PCDs in the injectable pre-formed hydrogels (CHT/PCDi/PCDs), which could be further fine-tuned to enhance their performance in biomedical applications.Consejo Nacional de Ciencia, Tecnología e Innovación Tecnológica - ConcytecengMDPI AGPolymersinfo:eu-repo/semantics/openAccesshttps://creativecommons.org/licenses/by/4.0/Watersoluble polymersChitosan-1Cyclodextrins-1Functional polymers-1Medical applications-1Polyelectrolytes-1Shear flow-1Shear thinning-1Stability-1Viscoelasticity-1Injectable hydrogels-1Insoluble polymers-1Self-healing-1Viscoelastic properties-1Hydrogels-1https://purl.org/pe-repo/ocde/ford#3.00.00-1Influence of the soluble-insoluble ratios of cyclodextrins polymers on the viscoelastic properties of injectable chitosan-based hydrogels for biomedical applicationinfo:eu-repo/semantics/articlereponame:CONCYTEC-Institucionalinstname:Consejo Nacional de Ciencia Tecnología e Innovacióninstacron:CONCYTEC#PLACEHOLDER_PARENT_METADATA_VALUE##PLACEHOLDER_PARENT_METADATA_VALUE##PLACEHOLDER_PARENT_METADATA_VALUE##PLACEHOLDER_PARENT_METADATA_VALUE##PLACEHOLDER_PARENT_METADATA_VALUE##PLACEHOLDER_PARENT_METADATA_VALUE#20.500.12390/659oai:repositorio.concytec.gob.pe:20.500.12390/6592024-05-30 15:22:35.908https://creativecommons.org/licenses/by/4.0/info:eu-repo/semantics/openAccesshttp://purl.org/coar/access_right/c_14cbinfo:eu-repo/semantics/closedAccessmetadata only accesshttps://repositorio.concytec.gob.peRepositorio Institucional CONCYTECrepositorio@concytec.gob.pe#PLACEHOLDER_PARENT_METADATA_VALUE##PLACEHOLDER_PARENT_METADATA_VALUE##PLACEHOLDER_PARENT_METADATA_VALUE##PLACEHOLDER_PARENT_METADATA_VALUE##PLACEHOLDER_PARENT_METADATA_VALUE##PLACEHOLDER_PARENT_METADATA_VALUE#<Publication xmlns="https://www.openaire.eu/cerif-profile/1.1/" id="b811ded2-2956-4bba-8e1c-9ba3d9477584"> <Type xmlns="https://www.openaire.eu/cerif-profile/vocab/COAR_Publication_Types">http://purl.org/coar/resource_type/c_1843</Type> <Language>eng</Language> <Title>Influence of the soluble-insoluble ratios of cyclodextrins polymers on the viscoelastic properties of injectable chitosan-based hydrogels for biomedical application</Title> <PublishedIn> <Publication> <Title>Polymers</Title> </Publication> </PublishedIn> <PublicationDate>2019</PublicationDate> <DOI>https://doi.org/10.3390/polym11020214</DOI> <SCP-Number>2-s2.0-85060655566</SCP-Number> <Authors> <Author> <DisplayName>Palomino-Durand C.</DisplayName> <Person id="rp01471" /> <Affiliation> <OrgUnit> </OrgUnit> </Affiliation> </Author> <Author> <DisplayName>Lopez M.</DisplayName> <Person id="rp00741" /> <Affiliation> <OrgUnit> </OrgUnit> </Affiliation> </Author> <Author> <DisplayName>Cazaux F.</DisplayName> <Person id="rp01472" /> <Affiliation> <OrgUnit> </OrgUnit> </Affiliation> </Author> <Author> <DisplayName>Martel B.</DisplayName> <Person id="rp01189" /> <Affiliation> <OrgUnit> </OrgUnit> </Affiliation> </Author> <Author> <DisplayName>Blanchemain N.</DisplayName> <Person id="rp01193" /> <Affiliation> <OrgUnit> </OrgUnit> </Affiliation> </Author> <Author> <DisplayName>Chai F.</DisplayName> <Person id="rp01187" /> <Affiliation> <OrgUnit> </OrgUnit> </Affiliation> </Author> </Authors> <Editors> </Editors> <Publishers> <Publisher> <DisplayName>MDPI AG</DisplayName> <OrgUnit /> </Publisher> </Publishers> <License>https://creativecommons.org/licenses/by/4.0/</License> <Keyword>Watersoluble polymers</Keyword> <Keyword>Chitosan</Keyword> <Keyword>Cyclodextrins</Keyword> <Keyword>Functional polymers</Keyword> <Keyword>Medical applications</Keyword> <Keyword>Polyelectrolytes</Keyword> <Keyword>Shear flow</Keyword> <Keyword>Shear thinning</Keyword> <Keyword>Stability</Keyword> <Keyword>Viscoelasticity</Keyword> <Keyword>Injectable hydrogels</Keyword> <Keyword>Insoluble polymers</Keyword> <Keyword>Self-healing</Keyword> <Keyword>Viscoelastic properties</Keyword> <Keyword>Hydrogels</Keyword> <Abstract>Injectable pre-formed physical hydrogels provide many advantages for biomedical applications. Polyelectrolyte complexes (PEC) formed between cationic chitosan (CHT) and anionic polymers of cyclodextrin (PCD) render a hydrogel of great interest. Given the difference between water-soluble (PCDs) and water-insoluble PCD (PCDi) in the extension of polymerization, the present study aims to explore their impact on the formation and properties of CHT/PCD hydrogel obtained from the variable ratios of PCDi and PCDs in the formulation. Hydrogels CHT/PCDi/PCDs at weight ratios of 3:0:3, 3:1.5:1.5, and 3:3:0 were elaborated in a double⁻syringe system. The chemical composition, microstructure, viscoelastic properties, injectability, and structural integrity of the hydrogels were investigated. The cytotoxicity of the hydrogel was also evaluated by indirect contact with pre-osteoblast cells. Despite having similar shear⁻thinning and self-healing behaviors, the three hydrogels showed a marked difference in their rheological characteristics, injectability, structural stability, etc., depending on their PCDi and PCDs contents. Among the three, all the best above-mentioned properties, in addition to a high cytocompatibility, were found in the hydrogel 3:1.5:1.5. For the first time, we gained a deeper understanding of the role of the PCDi/PCDs in the injectable pre-formed hydrogels (CHT/PCDi/PCDs), which could be further fine-tuned to enhance their performance in biomedical applications.</Abstract> <Access xmlns="http://purl.org/coar/access_right" > </Access> </Publication> -1 |
| score |
13.394457 |
Nota importante:
La información contenida en este registro es de entera responsabilidad de la institución que gestiona el repositorio institucional donde esta contenido este documento o set de datos. El CONCYTEC no se hace responsable por los contenidos (publicaciones y/o datos) accesibles a través del Repositorio Nacional Digital de Ciencia, Tecnología e Innovación de Acceso Abierto (ALICIA).
La información contenida en este registro es de entera responsabilidad de la institución que gestiona el repositorio institucional donde esta contenido este documento o set de datos. El CONCYTEC no se hace responsable por los contenidos (publicaciones y/o datos) accesibles a través del Repositorio Nacional Digital de Ciencia, Tecnología e Innovación de Acceso Abierto (ALICIA).
