Is glucose-6-phosphate dehydrogenase deficiency more prevalent in Carrion's disease endemic areas in Latin America?

• Autores: Mazulis F., Weilg C., Alva-Urcia C., Pons M.J., del Valle Mendoza J.
• Formato: otro
• Fecha de Publicación: 2015
• Institución: Consejo Nacional de Ciencia Tecnología e Innovación
• Repositorio: CONCYTEC-Institucional
• Lenguaje: inglés
• OAI Identifier: oai:repositorio.concytec.gob.pe:20.500.12390/667
• Enlace del recurso: https://hdl.handle.net/20.500.12390/667; https://doi.org/10.1016/j.apjtm.2015.11.014
• Nivel de acceso: acceso abierto
• Materia: glucose 6 phosphate dehydrogenase; Andean; Bartonella bacilliformis; Carrion disease; cell invasion; disease association; endemic disease; enzyme activity; https://purl.org/pe-repo/ocde/ford#3.02.06

Glucose-6-phosphate dehydrogenase (G6PD) is a cytoplasmic enzyme with an important function in cell oxidative damage prevention. Erythrocytes have a predisposition towards oxidized environments due to their lack of mitochondria, giving G6PD a major role in its stability. G6PD deficiency (G6PDd) is the most common enzyme deficiency in humans; it affects approximately 400 million individuals worldwide. The overall G6PDd allele frequency across malaria endemic countries is estimated to be 8%, corresponding to approximately 220 million males and 133 million females. However, there are no reports on the prevalence of G6PDd in Andean communities where bartonellosis is prevalent.