Biodereplication approach for antimalarial drugs in complex extracts mixtures: active compounds from the insect Pyrrhocoris apterus
Descripción del Articulo
Consejo Nacional de Ciencia y Tecnología (CONCYTEC) is acknowledged for PhD funding of Pedro Vásquez-Ocmín; Karine Leblanc for supporting in MS analyses.
| Autores: | , , , , , , |
|---|---|
| Formato: | objeto de conferencia |
| Fecha de Publicación: | 2016 |
| Institución: | Consejo Nacional de Ciencia Tecnología e Innovación |
| Repositorio: | CONCYTEC-Institucional |
| Lenguaje: | inglés |
| OAI Identifier: | oai:repositorio.concytec.gob.pe:20.500.12390/1025 |
| Enlace del recurso: | https://hdl.handle.net/20.500.12390/1025 https://doi.org/10.1055/s-0036-1596283 |
| Nivel de acceso: | acceso abierto |
| Materia: | https://purl.org/pe-repo/ocde/ford#3.01.05 |
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CONC_41b06cd59a519fa9751793999deff917 |
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oai:repositorio.concytec.gob.pe:20.500.12390/1025 |
| network_acronym_str |
CONC |
| network_name_str |
CONCYTEC-Institucional |
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4689 |
| dc.title.none.fl_str_mv |
Biodereplication approach for antimalarial drugs in complex extracts mixtures: active compounds from the insect Pyrrhocoris apterus |
| title |
Biodereplication approach for antimalarial drugs in complex extracts mixtures: active compounds from the insect Pyrrhocoris apterus |
| spellingShingle |
Biodereplication approach for antimalarial drugs in complex extracts mixtures: active compounds from the insect Pyrrhocoris apterus Vasquez-Ocmin, P https://purl.org/pe-repo/ocde/ford#3.01.05 https://purl.org/pe-repo/ocde/ford#3.01.05 |
| title_short |
Biodereplication approach for antimalarial drugs in complex extracts mixtures: active compounds from the insect Pyrrhocoris apterus |
| title_full |
Biodereplication approach for antimalarial drugs in complex extracts mixtures: active compounds from the insect Pyrrhocoris apterus |
| title_fullStr |
Biodereplication approach for antimalarial drugs in complex extracts mixtures: active compounds from the insect Pyrrhocoris apterus |
| title_full_unstemmed |
Biodereplication approach for antimalarial drugs in complex extracts mixtures: active compounds from the insect Pyrrhocoris apterus |
| title_sort |
Biodereplication approach for antimalarial drugs in complex extracts mixtures: active compounds from the insect Pyrrhocoris apterus |
| author |
Vasquez-Ocmin, P |
| author_facet |
Vasquez-Ocmin, P Suyyagh-Albouz, S Cojean, S Beniddir, M Loiseau, P Figadere, B Maciuk, A |
| author_role |
author |
| author2 |
Suyyagh-Albouz, S Cojean, S Beniddir, M Loiseau, P Figadere, B Maciuk, A |
| author2_role |
author author author author author author |
| dc.contributor.author.fl_str_mv |
Vasquez-Ocmin, P Suyyagh-Albouz, S Cojean, S Beniddir, M Loiseau, P Figadere, B Maciuk, A |
| dc.subject.none.fl_str_mv |
https://purl.org/pe-repo/ocde/ford#3.01.05 |
| topic |
https://purl.org/pe-repo/ocde/ford#3.01.05 https://purl.org/pe-repo/ocde/ford#3.01.05 |
| dc.subject.ocde.none.fl_str_mv |
https://purl.org/pe-repo/ocde/ford#3.01.05 |
| description |
Consejo Nacional de Ciencia y Tecnología (CONCYTEC) is acknowledged for PhD funding of Pedro Vásquez-Ocmín; Karine Leblanc for supporting in MS analyses. |
| publishDate |
2016 |
| dc.date.accessioned.none.fl_str_mv |
2024-05-30T23:13:38Z |
| dc.date.available.none.fl_str_mv |
2024-05-30T23:13:38Z |
| dc.date.issued.fl_str_mv |
2016 |
| dc.type.none.fl_str_mv |
info:eu-repo/semantics/conferenceObject |
| format |
conferenceObject |
| dc.identifier.uri.none.fl_str_mv |
https://hdl.handle.net/20.500.12390/1025 |
| dc.identifier.doi.none.fl_str_mv |
https://doi.org/10.1055/s-0036-1596283 |
| dc.identifier.isi.none.fl_str_mv |
411789300107 |
| url |
https://hdl.handle.net/20.500.12390/1025 https://doi.org/10.1055/s-0036-1596283 |
| identifier_str_mv |
411789300107 |
| dc.language.iso.none.fl_str_mv |
eng |
| language |
eng |
| dc.rights.none.fl_str_mv |
info:eu-repo/semantics/openAccess |
| eu_rights_str_mv |
openAccess |
| dc.publisher.none.fl_str_mv |
Thieme |
| publisher.none.fl_str_mv |
Thieme |
| dc.source.none.fl_str_mv |
reponame:CONCYTEC-Institucional instname:Consejo Nacional de Ciencia Tecnología e Innovación instacron:CONCYTEC |
| instname_str |
Consejo Nacional de Ciencia Tecnología e Innovación |
| instacron_str |
CONCYTEC |
| institution |
CONCYTEC |
| reponame_str |
CONCYTEC-Institucional |
| collection |
CONCYTEC-Institucional |
| repository.name.fl_str_mv |
Repositorio Institucional CONCYTEC |
| repository.mail.fl_str_mv |
repositorio@concytec.gob.pe |
| _version_ |
1844883003453472768 |
| spelling |
Publicationrp00833500rp00826500rp00835500rp01954500rp00830500rp00832500rp00829500Vasquez-Ocmin, PSuyyagh-Albouz, SCojean, SBeniddir, MLoiseau, PFigadere, BMaciuk, A2024-05-30T23:13:38Z2024-05-30T23:13:38Z2016https://hdl.handle.net/20.500.12390/1025https://doi.org/10.1055/s-0036-1596283411789300107Consejo Nacional de Ciencia y Tecnología (CONCYTEC) is acknowledged for PhD funding of Pedro Vásquez-Ocmín; Karine Leblanc for supporting in MS analyses.Malaria remains the most important global public health problem, with an estimated 214 million cases and 438 000 deaths in 2015, principally under 5-years old children [1]. Antimalarial drugs resistance permanent rising calls for new active molecules research against Plasmodium. The principal antimalarial drugs mechanism consists in interrupted heme crystallization in parasite erythrocytic phase, perturbating his waste-sorting strategy [2]. With a target-based approach, we developed a method which identifies heme-active molecule adduct in a complex extract (m/z for heme = 616) by mass spectroscopy (Q-TOF MS). This in vitro miniaturized biodereplication is based on a medium mimicking the parasite digestive vacuole (pH = 4.8) [3]. Application of the method was realized on a methanolic extract of Pyrrhocoris apterus insect (Pyrrhocoridae) (IC50 of extract = 80 ng/mL, Plasmodium falciparum 3D7 chloroquine-sensible strain). Active compounds were identified by m/z adduct (X + 616) using molecular networking4. Successive fractionation of active fractions was performed by several chromatography methods and structural identification was performed by 600 MHz NMR.Consejo Nacional de Ciencia, Tecnología e Innovación Tecnológica - ConcytecengThiemeinfo:eu-repo/semantics/openAccesshttps://purl.org/pe-repo/ocde/ford#3.01.05https://purl.org/pe-repo/ocde/ford#3.01.05-1Biodereplication approach for antimalarial drugs in complex extracts mixtures: active compounds from the insect Pyrrhocoris apterusinfo:eu-repo/semantics/conferenceObjectreponame:CONCYTEC-Institucionalinstname:Consejo Nacional de Ciencia Tecnología e Innovacióninstacron:CONCYTEC#PLACEHOLDER_PARENT_METADATA_VALUE##PLACEHOLDER_PARENT_METADATA_VALUE##PLACEHOLDER_PARENT_METADATA_VALUE##PLACEHOLDER_PARENT_METADATA_VALUE##PLACEHOLDER_PARENT_METADATA_VALUE##PLACEHOLDER_PARENT_METADATA_VALUE##PLACEHOLDER_PARENT_METADATA_VALUE#20.500.12390/1025oai:repositorio.concytec.gob.pe:20.500.12390/10252024-05-30 15:23:35.578http://purl.org/coar/access_right/c_14cbinfo:eu-repo/semantics/closedAccessmetadata only accesshttps://repositorio.concytec.gob.peRepositorio Institucional CONCYTECrepositorio@concytec.gob.pe#PLACEHOLDER_PARENT_METADATA_VALUE##PLACEHOLDER_PARENT_METADATA_VALUE##PLACEHOLDER_PARENT_METADATA_VALUE##PLACEHOLDER_PARENT_METADATA_VALUE##PLACEHOLDER_PARENT_METADATA_VALUE##PLACEHOLDER_PARENT_METADATA_VALUE##PLACEHOLDER_PARENT_METADATA_VALUE#<Publication xmlns="https://www.openaire.eu/cerif-profile/1.1/" id="9779af7a-0f4b-4be7-8379-7fa28f24f043"> <Type xmlns="https://www.openaire.eu/cerif-profile/vocab/COAR_Publication_Types">http://purl.org/coar/resource_type/c_1843</Type> <Language>eng</Language> <Title>Biodereplication approach for antimalarial drugs in complex extracts mixtures: active compounds from the insect Pyrrhocoris apterus</Title> <PublishedIn> <Publication> </Publication> </PublishedIn> <PublicationDate>2016</PublicationDate> <DOI>https://doi.org/10.1055/s-0036-1596283</DOI> <ISI-Number>411789300107</ISI-Number> <Authors> <Author> <DisplayName>Vasquez-Ocmin, P</DisplayName> <Person id="rp00833" /> <Affiliation> <OrgUnit> </OrgUnit> </Affiliation> </Author> <Author> <DisplayName>Suyyagh-Albouz, S</DisplayName> <Person id="rp00826" /> <Affiliation> <OrgUnit> </OrgUnit> </Affiliation> </Author> <Author> <DisplayName>Cojean, S</DisplayName> <Person id="rp00835" /> <Affiliation> <OrgUnit> </OrgUnit> </Affiliation> </Author> <Author> <DisplayName>Beniddir, M</DisplayName> <Person id="rp01954" /> <Affiliation> <OrgUnit> </OrgUnit> </Affiliation> </Author> <Author> <DisplayName>Loiseau, P</DisplayName> <Person id="rp00830" /> <Affiliation> <OrgUnit> </OrgUnit> </Affiliation> </Author> <Author> <DisplayName>Figadere, B</DisplayName> <Person id="rp00832" /> <Affiliation> <OrgUnit> </OrgUnit> </Affiliation> </Author> <Author> <DisplayName>Maciuk, A</DisplayName> <Person id="rp00829" /> <Affiliation> <OrgUnit> </OrgUnit> </Affiliation> </Author> </Authors> <Editors> </Editors> <Publishers> <Publisher> <DisplayName>Thieme</DisplayName> <OrgUnit /> </Publisher> </Publishers> <Keyword>https://purl.org/pe-repo/ocde/ford#3.01.05</Keyword> <Abstract>Malaria remains the most important global public health problem, with an estimated 214 million cases and 438 000 deaths in 2015, principally under 5-years old children [1]. Antimalarial drugs resistance permanent rising calls for new active molecules research against Plasmodium. The principal antimalarial drugs mechanism consists in interrupted heme crystallization in parasite erythrocytic phase, perturbating his waste-sorting strategy [2]. With a target-based approach, we developed a method which identifies heme-active molecule adduct in a complex extract (m/z for heme = 616) by mass spectroscopy (Q-TOF MS). This in vitro miniaturized biodereplication is based on a medium mimicking the parasite digestive vacuole (pH = 4.8) [3]. Application of the method was realized on a methanolic extract of Pyrrhocoris apterus insect (Pyrrhocoridae) (IC50 of extract = 80 ng/mL, Plasmodium falciparum 3D7 chloroquine-sensible strain). Active compounds were identified by m/z adduct (X + 616) using molecular networking4. Successive fractionation of active fractions was performed by several chromatography methods and structural identification was performed by 600 MHz NMR.</Abstract> <Access xmlns="http://purl.org/coar/access_right" > </Access> </Publication> -1 |
| score |
13.08006 |
Nota importante:
La información contenida en este registro es de entera responsabilidad de la institución que gestiona el repositorio institucional donde esta contenido este documento o set de datos. El CONCYTEC no se hace responsable por los contenidos (publicaciones y/o datos) accesibles a través del Repositorio Nacional Digital de Ciencia, Tecnología e Innovación de Acceso Abierto (ALICIA).
La información contenida en este registro es de entera responsabilidad de la institución que gestiona el repositorio institucional donde esta contenido este documento o set de datos. El CONCYTEC no se hace responsable por los contenidos (publicaciones y/o datos) accesibles a través del Repositorio Nacional Digital de Ciencia, Tecnología e Innovación de Acceso Abierto (ALICIA).
