Chronic hypoxia induces modification of the N-methyl-D-aspartate receptor in rat brain

Descripción del Articulo

This work was supported in part by a grant from the Consejo Nacional de Ciencia y Tecnologfa (CONCYTEC) of Perti. (+)-MK-801 was generously supplied by Dr. Leslie Iversen (Merck, Sharpe and Dohme, UK).
Detalles Bibliográficos
Autores: Pichiule P., Chávez J.C., Boero J., Arregui A.
Formato: artículo
Fecha de Publicación:1996
Institución:Consejo Nacional de Ciencia Tecnología e Innovación
Repositorio:CONCYTEC-Institucional
Lenguaje:inglés
OAI Identifier:oai:repositorio.concytec.gob.pe:20.500.12390/785
Enlace del recurso:https://hdl.handle.net/20.500.12390/785
https://doi.org/10.1016/S0304-3940(96)13113-X
Nivel de acceso:acceso abierto
Materia:n methyl dextro aspartic acid receptor blocking agent
dizocilpine
glutamic acid
glycine
n methyl dextro aspartic acid receptor
animal experiment
animal model
animal tissue
id CONC_2d2e0486161447b34b3822ff8ac9fa09
oai_identifier_str oai:repositorio.concytec.gob.pe:20.500.12390/785
network_acronym_str CONC
network_name_str CONCYTEC-Institucional
repository_id_str 4689
dc.title.none.fl_str_mv Chronic hypoxia induces modification of the N-methyl-D-aspartate receptor in rat brain
title Chronic hypoxia induces modification of the N-methyl-D-aspartate receptor in rat brain
spellingShingle Chronic hypoxia induces modification of the N-methyl-D-aspartate receptor in rat brain
Pichiule P.
n methyl dextro aspartic acid receptor blocking agent
dizocilpine
glutamic acid
glycine
n methyl dextro aspartic acid receptor
animal experiment
animal model
animal tissue
title_short Chronic hypoxia induces modification of the N-methyl-D-aspartate receptor in rat brain
title_full Chronic hypoxia induces modification of the N-methyl-D-aspartate receptor in rat brain
title_fullStr Chronic hypoxia induces modification of the N-methyl-D-aspartate receptor in rat brain
title_full_unstemmed Chronic hypoxia induces modification of the N-methyl-D-aspartate receptor in rat brain
title_sort Chronic hypoxia induces modification of the N-methyl-D-aspartate receptor in rat brain
author Pichiule P.
author_facet Pichiule P.
Chávez J.C.
Boero J.
Arregui A.
author_role author
author2 Chávez J.C.
Boero J.
Arregui A.
author2_role author
author
author
dc.contributor.author.fl_str_mv Pichiule P.
Chávez J.C.
Boero J.
Arregui A.
dc.subject.none.fl_str_mv n methyl dextro aspartic acid receptor blocking agent
topic n methyl dextro aspartic acid receptor blocking agent
dizocilpine
glutamic acid
glycine
n methyl dextro aspartic acid receptor
animal experiment
animal model
animal tissue
dc.subject.es_PE.fl_str_mv dizocilpine
glutamic acid
glycine
n methyl dextro aspartic acid receptor
animal experiment
animal model
animal tissue
description This work was supported in part by a grant from the Consejo Nacional de Ciencia y Tecnologfa (CONCYTEC) of Perti. (+)-MK-801 was generously supplied by Dr. Leslie Iversen (Merck, Sharpe and Dohme, UK).
publishDate 1996
dc.date.accessioned.none.fl_str_mv 2024-05-30T23:13:38Z
dc.date.available.none.fl_str_mv 2024-05-30T23:13:38Z
dc.date.issued.fl_str_mv 1996
dc.type.none.fl_str_mv info:eu-repo/semantics/article
format article
dc.identifier.uri.none.fl_str_mv https://hdl.handle.net/20.500.12390/785
dc.identifier.doi.none.fl_str_mv https://doi.org/10.1016/S0304-3940(96)13113-X
dc.identifier.scopus.none.fl_str_mv 2-s2.0-0030296304
url https://hdl.handle.net/20.500.12390/785
https://doi.org/10.1016/S0304-3940(96)13113-X
identifier_str_mv 2-s2.0-0030296304
dc.language.iso.none.fl_str_mv eng
language eng
dc.relation.ispartof.none.fl_str_mv Neuroscience Letters
dc.rights.none.fl_str_mv info:eu-repo/semantics/openAccess
eu_rights_str_mv openAccess
dc.publisher.en.fl_str_mv Elsevier
dc.source.none.fl_str_mv reponame:CONCYTEC-Institucional
instname:Consejo Nacional de Ciencia Tecnología e Innovación
instacron:CONCYTEC
instname_str Consejo Nacional de Ciencia Tecnología e Innovación
instacron_str CONCYTEC
institution CONCYTEC
reponame_str CONCYTEC-Institucional
collection CONCYTEC-Institucional
repository.name.fl_str_mv Repositorio Institucional CONCYTEC
repository.mail.fl_str_mv repositorio@concytec.gob.pe
_version_ 1844883087604842496
spelling Publicationrp02021600rp02023600rp02022600rp02024600Pichiule P.Chávez J.C.Boero J.Arregui A.2024-05-30T23:13:38Z2024-05-30T23:13:38Z1996https://hdl.handle.net/20.500.12390/785https://doi.org/10.1016/S0304-3940(96)13113-X2-s2.0-0030296304This work was supported in part by a grant from the Consejo Nacional de Ciencia y Tecnologfa (CONCYTEC) of Perti. (+)-MK-801 was generously supplied by Dr. Leslie Iversen (Merck, Sharpe and Dohme, UK).This study examined [3H]MK-801 binding to the N-methyl-D-aspartate (NMDA) receptor in membranes prepared from cerebral cortex, hippocampus and corpus striatum of 3 week old rats exposed to 10 weeks of intermittent hypobaric hypoxia (4300 m; 450 Torr) and compared results wiLh those of normoxic controls. The cortex, hippocampus and striatum of hypoxic animals had a 36, 35 and 31% reduction in binding sites (Bmax) and a 29, 32 and 17% decrease (reflecting increased affinity) in the dissociation constant (Kd) when compared to controls. In the cerebral cortex, both glutamate (100 #M) and glycine (10 #M) enhanced [3H]MK-801 binding by two to 3- fold: Coagonist glutamate, however, had a higher ECs0 (0.44 #M) in the hypoxic cortical membranes when compared to controls (0.28 #M). No significant differences were found in the ECs0 of glycine. The results show that the NMDA receptor is altered in several brain regions of rats developing in a hypoxic environment.Consejo Nacional de Ciencia, Tecnología e Innovación Tecnológica - ConcytecengElsevierNeuroscience Lettersinfo:eu-repo/semantics/openAccessn methyl dextro aspartic acid receptor blocking agentdizocilpine-1glutamic acid-1glycine-1n methyl dextro aspartic acid receptor-1animal experiment-1animal model-1animal tissue-1Chronic hypoxia induces modification of the N-methyl-D-aspartate receptor in rat braininfo:eu-repo/semantics/articlereponame:CONCYTEC-Institucionalinstname:Consejo Nacional de Ciencia Tecnología e Innovacióninstacron:CONCYTEC#PLACEHOLDER_PARENT_METADATA_VALUE##PLACEHOLDER_PARENT_METADATA_VALUE##PLACEHOLDER_PARENT_METADATA_VALUE#20.500.12390/785oai:repositorio.concytec.gob.pe:20.500.12390/7852025-09-24 10:03:33.915http://purl.org/coar/access_right/c_14cbinfo:eu-repo/semantics/closedAccessmetadata only accesshttps://repositorio.concytec.gob.peRepositorio Institucional CONCYTECrepositorio@concytec.gob.pe#PLACEHOLDER_PARENT_METADATA_VALUE##PLACEHOLDER_PARENT_METADATA_VALUE##PLACEHOLDER_PARENT_METADATA_VALUE##PLACEHOLDER_PARENT_METADATA_VALUE#<Publication xmlns="https://www.openaire.eu/cerif-profile/1.1/" id="46e73252-d815-457b-ab92-46ffefcf289e"> <Type xmlns="https://www.openaire.eu/cerif-profile/vocab/COAR_Publication_Types">http://purl.org/coar/resource_type/c_1843</Type> <Language>eng</Language> <Title>Chronic hypoxia induces modification of the N-methyl-D-aspartate receptor in rat brain</Title> <PublishedIn> <Publication> <Title>Neuroscience Letters</Title> </Publication> </PublishedIn> <PublicationDate>1996</PublicationDate> <DOI>https://doi.org/10.1016/S0304-3940(96)13113-X</DOI> <SCP-Number>2-s2.0-0030296304</SCP-Number> <Authors> <Author> <DisplayName>Pichiule P.</DisplayName> <Person id="rp02021" /> <Affiliation> <OrgUnit> </OrgUnit> </Affiliation> </Author> <Author> <DisplayName>Chávez J.C.</DisplayName> <Person id="rp02023" /> <Affiliation> <OrgUnit> </OrgUnit> </Affiliation> </Author> <Author> <DisplayName>Boero J.</DisplayName> <Person id="rp02022" /> <Affiliation> <OrgUnit> </OrgUnit> </Affiliation> </Author> <Author> <DisplayName>Arregui A.</DisplayName> <Person id="rp02024" /> <Affiliation> <OrgUnit> </OrgUnit> </Affiliation> </Author> </Authors> <Editors> </Editors> <Publishers> <Publisher> <DisplayName>Elsevier</DisplayName> <OrgUnit /> </Publisher> </Publishers> <Keyword>n methyl dextro aspartic acid receptor blocking agent</Keyword> <Keyword>dizocilpine</Keyword> <Keyword>glutamic acid</Keyword> <Keyword>glycine</Keyword> <Keyword>n methyl dextro aspartic acid receptor</Keyword> <Keyword>animal experiment</Keyword> <Keyword>animal model</Keyword> <Keyword>animal tissue</Keyword> <Abstract>This study examined [3H]MK-801 binding to the N-methyl-D-aspartate (NMDA) receptor in membranes prepared from cerebral cortex, hippocampus and corpus striatum of 3 week old rats exposed to 10 weeks of intermittent hypobaric hypoxia (4300 m; 450 Torr) and compared results wiLh those of normoxic controls. The cortex, hippocampus and striatum of hypoxic animals had a 36, 35 and 31% reduction in binding sites (Bmax) and a 29, 32 and 17% decrease (reflecting increased affinity) in the dissociation constant (Kd) when compared to controls. In the cerebral cortex, both glutamate (100 #M) and glycine (10 #M) enhanced [3H]MK-801 binding by two to 3- fold: Coagonist glutamate, however, had a higher ECs0 (0.44 #M) in the hypoxic cortical membranes when compared to controls (0.28 #M). No significant differences were found in the ECs0 of glycine. The results show that the NMDA receptor is altered in several brain regions of rats developing in a hypoxic environment.</Abstract> <Access xmlns="http://purl.org/coar/access_right" > </Access> </Publication> -1
score 13.941018
Chronic hypoxia induces modification of the N-methyl-D-aspartate receptor in rat brain
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La información contenida en este registro es de entera responsabilidad de la institución que gestiona el repositorio institucional donde esta contenido este documento o set de datos. El CONCYTEC no se hace responsable por los contenidos (publicaciones y/o datos) accesibles a través del Repositorio Nacional Digital de Ciencia, Tecnología e Innovación de Acceso Abierto (ALICIA).

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