Wound Healing Activity of an Ointment from Solanum tuberosum L. "Tumbay Yellow Potato" on Mus musculus Balb/c

• Autores: Rosas-Cruz G.P., Silva-Correa C.R., Calderón-Peña A.A., Villarreal-La Torre V.E., Aspajo-Villalaz C.L., Cruzado-Razco J.L., Rosario-Chávarri J.D., Rodríguez-Soto J.C., Pretel-Sevillano O.E., Sagástegui-Guarniz W.A., González-Siccha A.D.
• Formato: artículo
• Fecha de Publicación: 2020
• Institución: Consejo Nacional de Ciencia Tecnología e Innovación
• Repositorio: CONCYTEC-Institucional
• Lenguaje: inglés
• OAI Identifier: oai:repositorio.concytec.gob.pe:20.500.12390/2437
• Enlace del recurso: https://hdl.handle.net/20.500.12390/2437; https://doi.org/10.5530/PJ.2020.12.175
• Nivel de acceso: acceso abierto
• Materia: Yellow potato; Histology; Skin; Solanum tuberosum; Wound healing; http://purl.org/pe-repo/ocde/ford#3.02.27

Background: Solanum tuberosum L. is an Andean tuber that is mainly characterized by its antioxidant properties. Objective: To evaluate the healing activity of an S. tuberosum-based ointment on wounds induced in mice. Material and methods: Ethanolic extracts of peel and pulp of tubers of S. tuberosum "Tumbay yellow potato"were prepared, which were incorporated into 1% and 2% ointment formulations. Mus musculus Balb/c with induced wound were distributed in the following working groups: Group I (Negative Control), Group II (Positive Control: Neomycin, Polymyxin B and Bacitracin Ointment) and Groups III and IV (Ointment at 1 % and 2% of S. tuberosum extract, respectively), daily administration of topical treatments were carried out for 07 days. Wound closure was determined during the experimentation time, then euthanized with sodium pentobarbital 60 mg/kg b.w. (i.p.) to obtain skin samples for histopathological analysis. Results: Groups III and IV showed that better evidence of wound closure and scarring in the histopathological analysis, the greatest effect being in Group IV. Conclusions: S. tuberosum ointments show healing activity in induced wounds in mice, the most effective treatment being the 2% ointment formulation. © 2020 Phcogj.Com.