Nano Currents and the Beginning of Renal Damage: A Theoretical Model

• Autor: Nieto-Chaupis, Huber
• Formato: artículo
• Fecha de Publicación: 2020
• Institución: Universidad Autónoma del Perú
• Repositorio: AUTONOMA-Institucional
• Lenguaje: inglés
• OAI Identifier: oai:repositorio.autonoma.edu.pe:20.500.13067/1710
• Enlace del recurso: https://hdl.handle.net/20.500.13067/1710; https://doi.org/10.1109/CBMS49503.2020.00071
• Nivel de acceso: acceso restringido
• Materia: Proteins; Silicon compounds; Electric potential; Mathematical model; Electrodynamics; Sugar; https://purl.org/pe-repo/ocde/ford#2.02.04

In type-II diabetes patients, the renal damage can be triggered by the abundance of glucose for large periods. This leads a continuous flux of proteins through the inner kidneys layers that ends in the urine formation zone. Being the albumin one of these proteins and characterized by their size, the role of their negative charge electric might be a solid reason to deplete the charge along the podocytes as well as exerting electric forces on nefrin, therefore podocytes would be loosing their main functionalities as protector shield against giant proteins. In this paper we present a theoretical model based on the well-known Poissons equations and their closed-form solutions. Finally, from the angle of Physics, the renal damage can be perceived as formation of nano currents as consequence of the lost of charges on the podocytes.