Cervicovaginal interleukin-6 in the prediction of preterm delivery

• Autores: Reyna Villasmil, Eduardo, Mejia Montilla, Jorly, Reyna Villasmil, Nadia, Torres Cepeda, Duly, Santos Bolívar, Joel, Fernández Ramírez, Andreina
• Formato: artículo
• Fecha de Publicación: 2016
• Institución: Sociedad Peruana de Obstetricia y Ginecología
• Repositorio: Revista SPOG - Revista Peruana de Ginecología y Obstetricia
• Lenguaje: español
• OAI Identifier: oai:ojs.spog:article/1900
• Enlace del recurso: http://www.spog.org.pe/web/revista/index.php/RPGO/article/view/1900
• Nivel de acceso: acceso abierto

Objective: To establish the usefulness of cervicovaginal interleukin-6 concentrations for the prediction of preterm delivery. Design: Case-control study. Setting: Hospital Central “Dr. Urquinaona”, Maracaibo, Venezuela. Participants: Patients with preterm delivery (group A), as cases, and pregnant women with term delivery (group B), considered as controls. Interventions: Cervicovaginal secretion samples were obtained from both the external cervical os and vaginal fornix between 24 and 28 weeks of pregnancy. All patients were followed until delivery. Main outcome results: General characteristics, cervicovaginal interleukin-6 concentrations, and prognostic efficacy. Results: Mean gestational age at measurement of interleukin-6 cervicovaginal concentrations was 26.2 +/- 1.1 weeks in group A and 25.9 +/- 1.1 weeks in group B (p = ns). There were no significant differences in maternal age, body mass index and history of preterm labor (p = ns). Group A patients presented higher cervicovaginal interleukin-6 concentrations (195.8 +/- 74.4 pg/mL) than group B (123.4 +/- 69.6 pg/mL) (p < 0.0001). A cut-off value of 150 pg/dL had a value under the curve of 0.75 and presented a sensitivity of 63.4%, a specificity of 62.5%, a positive predictive value of 13.5% and a negative predictive value of 94.8%. Conclusion: Cervico-vaginal interleukin-6 concentrations appeared useful in the prediction of preterm delivery.