INTERRUPCIÓN DE GESTACIÓN EN PERRAS UTILIZANDO DEXAMETASONA ORAL

• Autores: Sánchez R., Alfonso, Saéz P., Lorena
• Formato: artículo
• Fecha de Publicación: 2006
• Institución: Universidad Nacional Mayor de San Marcos
• Repositorio: Revista UNMSM - Revista de Investigaciones Veterinarias del Perú
• Lenguaje: español
• OAI Identifier: oai:ojs.csi.unmsm:article/1460
• Enlace del recurso: https://revistasinvestigacion.unmsm.edu.pe/index.php/veterinaria/article/view/1460
• Nivel de acceso: acceso abierto

The purpose of this study was to describe reproductive and clinical parameters as aresult of dexamethasone administration in order to terminate unwanted pregnancy inbitches. Five pregnant adult bitches, clinically healthy, were used. Animals were orallyadministered 0.2 mg/kg of dexamethasone every 12 hours during 6 days and thereafter,the dose was gradually reduced till 0.02 mg/kg on day 10. Ultrasound scan, bodytemperature, plasma progesterone, and behaviour were recorded throughout the study.The gestation was satisfactorily interrupted in 4 out of 5 bitches, where absorption orabortion occurred between 7 to 16 days after the beginning of the treatment. In theremaining animal, the interruption was partial (absorption and birth of immature puppies).Body temperature felt 1.0 - 1.5 ºC prior to the absorption or abortion. Progesteroneconcentration descended at day 4 of treatment and absorption or abortion occurred afterprogesterone declined to <1 ng/ml. A greenish discharge was observed in abortions. Themore frequent side-effects observed were polydipsia and polyuria, whereas vomitingand anorexia was observed in smaller proportion. The administration of dexamethasonewould have a similar effect to the liberation of fetal cortisol in the normal mechanism ofthe parturition and therefore, it would be a medical alternative for the control of canineoverpopulation, particularly in those cases of unwanted pregnancy.
The purpose of this study was to describe reproductive and clinical parameters as a result of dexamethasone administration in order to terminate unwanted pregnancy in bitches. Five pregnant adult bitches, clinically healthy, were used. Animals were orally administered 0.2 mg/kg of dexamethasone every 12 hours during 6 days and thereafter, the dose was gradually reduced till 0.02 mg/kg on day 10. Ultrasound scan, body temperature, plasma progesterone, and behaviour were recorded throughout the study. The gestation was satisfactorily interrupted in 4 out of 5 bitches, where absorption or abortion occurred between 7 to 16 days after the beginning of the treatment. In the remaining animal, the interruption was partial (absorption and birth of immature puppies). Body temperature felt 1.0 - 1.5 ºC prior to the absorption or abortion. Progesterone concentration descended at day 4 of treatment and absorption or abortion occurred after progesterone declined to <1 ng/ml. A greenish discharge was observed in abortions. The more frequent side-effects observed were polydipsia and polyuria, whereas vomiting and anorexia was observed in smaller proportion. The administration of dexamethasone would have a similar effect to the liberation of fetal cortisol in the normal mechanism of the parturition and therefore, it would be a medical alternative for the control of canine overpopulation, particularly in those cases of unwanted pregnancy.