The evaluation of donors and blood components ensures quality therapy. Objective. To characterize donors, describe the availability of blood components, and analyze trends in transfusion-transmissible infections (TTIs). Methods. A descriptive-retrospective study was conducted using data from the Loreto Regional Blood Donation Center (2018–2022). Applicants aged over 18 years, screened serologically for HIV, hepatitis B, hepatitis C, HTLV, syphilis, and Chagas disease, were included. sociodemographic variables, deferrals, production, disposal of blood components, and TTI prevalence were analyzed through descriptive analysis. Results. In 2022, 72.5% of donors were eligible and 21.9% were deferred (2020), with low hemoglobin as the leading cause (30%). Male participation predominated (74.3%), as did the 25–44 age group (60%). Blood component production increased from 3487 to 7568 units,...