The flotation of sulfide mineral type with high silver content and the presence of As and Sb were studied. The mineral presented as chemical analysis 5.10 g/TM gold, 700.00 g/TM Ag, 3.9 % copper, 2.0 % of 1.2 % arsenic and antimony. The independent variable was considered the grain size in 3 levels: 55 % - #200, 60 % - #200, 65 % - #200. The other independent variable was the pH at 3 levels: 8.5, 10 and 11.5. The dependent variable was the percentage recovery of gold, copper and silver; and variable concentration ratio. The results show that if the pH is raised higher percentage copper recovery and increased concentration ratio is obtained, however decreases the percentage recovery of gold and silver, the particle size is observed that only affects the percentage recovery of copper and the concentration ratio. We conclude that pH significantly influences the rate of recovery of copper, g...