ABSTRACT: Objectives: To determine the association between maternal perinatal factors and early neonatal sepsis in a Chimbote hospital. Methodology: Analytical, cross-sectional, retrospective study and design of cases and controls. Fifty-one newborns with early neonatal sepsis (cases) and 51 healthy newborns (control) were compared, from the neonatology service of La Caleta hospital, period 2016-2020; using bivariate and multivariate statistics (odds ratio, 95% confidence interval, chi square and logistic regression p value). Results: The male sex was found to have an odds ratio: 2.07; 95% CI (0.93 to 4.61); prematurity odds ratio: 3.91, 95% CI (0.76 to 19.98); low birth weight odds ratio: 2.67, 95% CI (0.49 to 14.44); urinary tract infection odds ratio: 6.77, 95% CI (1.41 to 32.36); premature rupture of membranes> 18 hours odds ratio: 1.98, 95% CI (0.61 ...