Patients older than 50 years with a diagnosis of HIV / AIDS are a heterogeneous group with different epidemiological and clinical characteristics than the youngest ones. Objective: To establish the clinical and epidemiological characteristics of patients over 50 years with HIV / AIDS in the Regional Teaching Hospital of Trujillo. Material and method: Cross-sectional descriptive study. We worked with 127 clinical records of patients over 50 years of age with a diagnosis of HIV / AIDS in the Regional Teaching Hospital of Trujillo from 2005 to 2015. Results: 76.4% were male between 50-59 years, 63.8% had employment, 91.3% alcohol consumption, with 70.9% never using a condom, as a pattern of 100% sexual transmission, a CD4 of less than 200 cel / ml, with high viral load and clinical stage C in 72.4%, 66.1% and 61.4% respectively. Comorbidity associated with HIV / AIDS Pulmonary tuberculosis ...