Objective: To analyze the influence of long COVID-19 on daily life activities (DLA) in adults with non-transmissible disease (NTD) and to differentiate by disease severity. Methods: The research design was descriptive, cross-sectional explanatory in 100 adults older than 50 years, who gave verbal consent to participate in the study by phone. A format was developed to record sociodemographic characteristics, type and number of NTD and long COVID-19 presence (number of sequels). To determine the DLA, the Barthel index was used, which consists of 10 items that allow classifying the level of dependency to perform DLA. Data analysis in SPSS v25 included descriptive and inferential statistics. Results. The average age 63,8 years, 59% of the participants were women; 50% had only one NTD. From long COVID, 52% reported 5 to 7 sequels: 76% referred to fatigue, 51% insomnia, 50% alopecia, bone pain...