Objective: The review aimed to assess the structural changes in the craniofacial complex following maxillary expansion assisted by micro-implants, known as the “Miniscrew assisted rapid palatal expander” (MARPE) in patients with maxillary transverse deficiency. Materials and Methods: The research included a specific type of expander called “Maxillary Skeletal Expander” (MSE) the design features a posteriorly positioned screw aligned with the zygomatic buttress, supported by four micro-implants located paramedial to the midpalatal suture with bicortical engagement of the palatal vault and the nasal floor. Four databases (PubMed, Scopus, Embase and ScienceDirect) were reviewed until July 2024. Studies reporting skeletal and dentoalveolar changes in patients with transverse maxillary deficiency evaluated using cone-beam computed tomography (CBCT) were selected. The methodology was e...