The objective of this research was to analyze the influence of social isolation on the quality of life of the users of the Centro Adulto Mayor – Cartavio, 2021. I work with the deductive, statistical and basic type method, with a quantitative approach, of a non- experimental correlational design. , extracted the survey technique and the questionnaire as an instrument, analyzed 30 CAM users. Results, social isolation was located in the middle with 53.30%, followed by its dimensions of perception of social support, use of new technologies and social participation index, at the same level with 56.70%, 60% and 46, 70% high, respectively. Regarding the quality of life, it was located in the middle with 60%, and the physical, psychological health, interpersonal relationships and environment dimensions in the middle with 60%, 50%, 60%, 53.30 and 70%. Conclusion, a Pearson consequence of -0.68...