Background:Euphorbia huachahana (Klotzch & Garcke) Boissier (Huachangana)(EhKGBh)has been used for over a century for medicinal purposes in the Peruvian population; however, itssafety and possible toxic effects of use have not been reported. The purpose of this study was todetermine the acute hepatic and renal toxicity of EhKGBh in Holtzman rats. Methods: Analyticaland experimental study. The population consisted of 52 rats of both sexes weighing between 300 and350 g divided into four groups: G1 and G2 EhKGBh groups (26 rats each) and two control groups(10 rats each). The experimental group was administered EhKGBh at a single dose of 2000 mg/kg P.O.to demonstrate toxicity during the 14-day follow-up. A daily assessment of alanine aminotransferase(ALT), aspartate aminotransferase (AST), alkaline phosphatase (ALP), total bilirubin (TBIL), andconjugated bilirubin (CBIL) was performed. Resul...

Background:Euphorbia huachahana (Klotzch & Garcke) Boissier (Huachangana)(EhKGBh)has been used for over a century for medicinal purposes in the Peruvian population; however, itssafety and possible toxic effects of use have not been reported. The purpose of this study was todetermine the acute hepatic and renal toxicity of EhKGBh in Holtzman rats. Methods: Analyticaland experimental study. The population consisted of 52 rats of both sexes weighing between 300 and350 g divided into four groups: G1 and G2 EhKGBh groups (26 rats each) and two control groups(10 rats each). The experimental group was administered EhKGBh at a single dose of 2000 mg/kg P.O.to demonstrate toxicity during the 14-day follow-up. A daily assessment of alanine aminotransferase(ALT), aspartate aminotransferase (AST), alkaline phosphatase (ALP), total bilirubin (TBIL), andconjugated bilirubin (CBIL) was performed. Resul...

Background: Euphorbia huachahana (Klotzch & Garcke) Boissier (Huachangana) (EhKGBh) has been used for over a century for medicinal purposes in the Peruvian population; however, its safety and possible toxic effects of use have not been reported. The purpose of this study was to determine the acute hepatic and renal toxicity of EhKGBh in Holtzman rats. Methods: Analytical and experimental study. The population consisted of 52 rats of both sexes weighing between 300 and 350 g divided into four groups: G1 and G2 EhKGBh groups (26 rats each) and two control groups (10 rats each). The experimental group was administered EhKGBh at a single dose of 2000 mg/kg P.O. to demonstrate toxicity during the 14-day follow-up. A daily assessment of alanine aminotransferase (ALT), aspartate aminotransferase (AST), alkaline phosphatase (ALP), total bilirubin (TBIL), and conjugated bilirubin (CBIL) was perfo...