To determine the personal and environmental risk factors associated with the presence and absence of Malaria in people aged 18 to 65 years of both sexes attended at the IPRESS I-3 Santa Clara de Nanay Iquitos 2020. Quantitative study, with non-experimental design of Cases and Controls. The population was 705 people. The results were: In personal factors, a statistical association was found between the presence of Malaria and age (p = 0.005 < 0.05; OR = 5); sex (p = 0.048 < 0.05; OR = 3); marital status (p = 0.045 < 0.05; OR = 3); occupation (p = 0.047 < 0.05; OR = 3); Family income (p = 0.000 < 0.05; OR = 10) and history of Malaria (p = 0.000 < 0.05; OR = 36). In environmental factors, a statistical association was found between the presence of Malaria and the use of a well (p = 0.000 < 0.05; OR = 17); use of mosquito net (p = 0.000 < 0.05; OR = 17); overcrowding (p = 0.000 < 0.05; OR = ...