Introducción: La leucemia linfoblástica aguda (LLA) es una neoplasia con origen en médula ósea. Los trasplantes de progenitores hematopoyéticos (TPH) mejoran la supervivencia en pacientes candidatos, siendo el alogénico más utilizado. Además, existen factores que influyen en la sobrevida global (OS) y sobrevida libre de enfermedad (DFS). Objetivo: Determinar la OS y DFS a los 5 años de pacientes con LLA post-trasplante del Hospital Nacional Edgardo Rebagliati Martins (HNERM), 2016-2021. Métodos: Se realizó un estudio cohorte retrospectivo de 188 pacientes con LLA que recibieron TPH entre las fechas 2016-2021. Las curvas de Kaplan-Meier evaluaron la OS y DFS, y la prueba Log Rank se usó para el análisis bivariado. La regresión de Cox determinó el Hazard ratio entre las variables predictoras y la OS y DFS. Resultados: La OS y DFS a los 5 años fue 53.2% y 46.41% respectivame...

Parkinson’s disease (PD) is a gradually worsening neurodegenerative disorder affecting the nervous system, marked by a slow progression and varied symptoms. It is the second most common neurodegenerative disease, affecting over six million people in the world. Its multifactorial etiology includes environmental, genomic, and epigenetic factors. Clinical symptoms consist of non-motor and motor symptoms, with motor symptoms being the classic presentation. Therapeutic approaches encompass pharmacological, non-pharmacological, and surgical interventions. Traditional pharmacological treatment consists of administering drugs (MAOIs, DA, and levodopa), while emerging evidence explores the potential of antidiabetic agents for neuroprotection and gene therapy for attenuating parkinsonian symptoms. Non-pharmacological treatments, such as exercise, a calcium-rich diet, and adequate vitamin D suppl...

Stem cell therapy may present an effective treatment for metastatic brain cancer and glioblastoma. Here we posit the critical role of a leaky blood-brain barrier (BBB) as a key element for the development of brain metastases, specifically melanoma. By reviewing the immunological and inflammatory responses associated with BBB damage secondary to tumoral activity, we identify the involvement of this pathological process in the growth and formation of metastatic brain cancers. Likewise, we evaluate the hypothesis of regenerating impaired endothelial cells of the BBB and alleviating the damaged neurovascular unit to attenuate brain metastasis, using the endothelial progenitor cell (EPC) phenotype of bone marrow-derived mesenchymal stem cells. Specifically, there is a need to evaluate the efficacy for stem cell therapy to repair disruptions in the BBB and reduce inflammation in the brain, the...