The objective of the research was to determine the relationship between the level of knowledge and preventive practices in the transmission of COVID-19 in families of the young town of Tupac Amaru, Iquitos 2021. Methodology: the type of study was quantitative, descriptive, correlational; the design was nonexperimental, cross-sectional; population made up of 300 families and the sample of 108. The instruments were: questionnaire on the level of knowledge in COVID-19 (validity: 97.37%, reliability: 0.711; checklist of preventive practices (validity: 99.25%, reliability: 0.724 The results are: 48.1% families qualified with a high level of knowledge and 46.3% with a medium level, the greatest knowledge was: concept, transmission, risk of infection, severe symptoms, most affected organ and outside care. from home, and the least knowledge was in: incubation period, environments where the virus...