Introduction: Pre-exposure prophylaxis (PrEP) is a therapeutic scheme that has shown effectiveness in reducing the risk of HIV infection through sexual contact. PrEP has been used in various countries globally and in Latin America as a public health measure. In Peru, the greatest increase in HIV incidence in recent years has occurred in the age group of 20–29 years and 15–19 years, this being an important range to be able to implement prevention measures. Objectives: To determine the prevalence of awareness of HIV PrEP and to explore the knowledge and attitudes regarding its use among men who have sex with men (MSM) aged 18–29 years in Lima, Peru. Methods: Explanatory sequential mixed method study whose central component is quantitative. A survey (non-probabilistic descriptive cross-sectional) and a virtual interview (phenomenological approach) were used for data collection. Result...