Tuberculosis continues to be a global health and public health problem in developing countries (WORLD HEALTH ORGANIZATION, WHO. 2017). The objective of the present work was to determine the resistance factors of Mycobacterium tuberculosis in the Santa District hospital Isabel 2018. The study units were the medical records of patients diagnosed with resistance to Mycobacterium tuberculosis. A sample size was not calculated, since all the members of the population that met the selection criteria were studied. The highest percentage of resistance was found between 15 and 30 years and 51 to 70 years, both with 43%, the highest percentage of 71% resistance to Mycobacterium tuberculosis corresponds to the male sex, and the lowest percentage corresponds to sex. female with 29%, 43% is presented in users with single marital status, the highest percentage 71% were overweight and normal weight 29%...