This research was carried out in the guinea pig shed located within the National Autonomous University of Alto Amazonas-Yurimaguas headquarters, whose general objective was to evaluate the effect of levels of efficient microorganisms in the diet of weaned guinea pigs on productive parameters. The parameters evaluated were: food consumption, weight gain, feed conversion, mortality and economic value, using a population of 24 weaned guinea pigs of the Peru breed, using the 2x3 factorial statistical design, with three treatments and four repetitions and degree of reliability (P<0.05). They were distributed according to the following treatments: T0: 0% efficient microorganisms (ME); T1: 1.5% ME and T2: 3.0% ME. The results found of the accumulated food consumed were: T0: 1,625 kg; T1: 1,470 kg and T2: 1,632 kg, where statistical significance was observed, between the treatments under study (...