Since their appearance, antibiotics have been and are an important weapon for the treatment of many infectious diseases, some of which caused high mortality, and their use made it possible to significantly and notably reduce the morbidity and mortality of some of these diseases. Currently, in acute appendicitis, the prophylactic administration of antimicrobials is considered by many surgeons as important and indispensable as the application of the antisepsis rules during the intervention, with particular attention to the most effective agent. Bacterial resistance is a growing phenomenon characterized by a partial or total refractoriness of the microorganisms to the effect of the antibiotic generated mainly by the indiscriminate and irrational use of these and not only by the evolutionary pressure that is exerted in the therapeutic use. At Víctor Lazarte Echegaray Hospital in Trujillo, t...