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A.D., H.P., B.B., J.J., A.A.A. and E.M.C.F. were funded by the UK Medical Research Council (MRC), the UK Motor Neurone Disease Association (MNDA), the American Amyotrophic Lateral Sclerosis Association (ALSA) and the Rosetrees Trust. B.K. and L.G. were supported by the MNDA and the Thierry Latran Foundation. J.H. is funded by the MRC and the Brain Research Trust. A.M.M. is supported by a PhD studentship from CONCYTEC (through CIENCIACTIVA) and the UK Embassy in Perú. P.S. is funded by the MRC. A.I. is funded by the MNDA and the European Research Council. B.D. is supported by Wellcome Trust Core Award Grant Number 090532/Z/09/Z. P.F. is supported by a MRC/MNDA Lady Edith Wolfson Fellowship, the Rosetrees Trust and NIHR University College London Hospitals Biomedical Research Centre.