Failure of extubation in preterm infants is common and reintubation represents an increased risk of complications, so it is essential to identify factors associated with extubation success or failure. For this reason, the present work aims to determine the factors associated with extubation failure in preterm newborns treated in the neonatology service of Hospital Iquitos, 2019-2021. For this, an observational-analytical study was developed, having as a sample 19 intubated preterm newborns, from 28 to 36 weeks of gestational age. Concluding that the prevalence of extubation failure was 15.8%, regarding the clinical-epidemiological characteristics, gestational age presented a statistically significant association with extubation failure (28.3 weeks vs 31.8 weeks, p=0.016), other variables such as weight, Gender, type of delivery, antenatal corticosteroids, gestational hypertension, gestat...