Objective: To describe the prevalence and clinical and epidemiological characteristics of cognitive impairment in older adults from urban areas of the district of Iquitos during 2025. Methods: Prospective observational study with an analytical, cross-sectional design. A total of 399 adults aged 65 years and older from the district of Iquitos were enrolled and administered a sociodemographic questionnaire, a clinical questionnaire, and the Mini-Mental State Examination (MMSE). Results: Cognitive impairment was identified in 40.6% of older adults (95% CI: 35.8 to 45.4). In univariate analysis, 263 were women and 136 men; the mean age was 74.6 ± 7.1 years. Regarding marital status, 39.1% were married, and with respect to occupation, 50.6% reported being employed; mean years of schooling were 8.4 ± 3.4. Fifty older adults had diabetes only, 186 had hypertension only, and 21 had both diabet...