Background: Resin-modified glass ionomer cement (RM-GIC) is widely used in clinical dental procedures as a restorative material due to its chemical composition. It is known for its strong adhesion to dental structures and its fluoride content. However, fluoride in RM-GIC is insufficient for preventing the formation of carious lesions, making the use of fluoride gel and varnish necessary as preventive strategies. Nevertheless, there may be adverse interactions between RM-GIC and fluoride, which could compromise the properties of these restorative materials. Therefore, it is crucial to understand the physicochemical and biological properties of the products used in dental treatments. This experimental study aimed to evaluate the effect of the following fluorides: 2% neutral sodium fluoride (NaF), 1.23% acidulated phosphate fluoride (APF), and 0.1% fluoride varnish (7700 ppm F) in the mi-cr...