The consumption of milk is widespread in the world and extensive information is found on the effect of its consumption on health. This literature review aimed to collect and organize information on the diff erential composition of fatty acids in the milk of various mammals and show their relationship with human health. The method uses protocols and search criteria (PICOS), to obtain the information and perform the analysis. Th e results highlight the variation of the milk composition according to its animal origin, in the percentage of its macrocomponents (proteins, lipids, carbohydrates), microcomponents (minerals, vitamins) and other bioelements, as well as in the composition of these. The lipid macrocomponent provides the largest source of energy, polyunsaturated fatty acids (PUFAs) and fat-soluble vitamins required by breeding during lactation, being very variable according to the ma...