The present study aimed to phytochemically characterize and quantify the total polyphenol content in fruits of Syzygium paniculatum Gaertn., a little-studied species but with bioactive potential. Qualitative and semiquantitative phytochemical screening methods were used, as well as the Folin-Ciocalteu method to determine total phenols. The fruits were collected in Quito, Ecuador, and processed to obtain extracts with three hydroalcoholic mixtures: methanol-water (80%), ethanol-water (80%), and acetone-water (80%). Screening revealed abundant flavonoids and tannins, and moderate anthocyanidins and reducing sugars, while alkaloids, triterpenes, saponins, and other metabolites were not detected. Regarding the quantification of polyphenols, the results showed that the methanol-water extract (80%) presented the highest content (86.67 ± 1.94 mg EAG/100 g of dried fruit), followed by ethanol-w...