The present study aimed to determine the pharmacognostic study and to quantify the total flavonoids present in the crude extracts, ethanolic and juice of the fruit of Cyphomandra betacea "tomato of tree", whose sample was collected in the district of Lucma, Gran Chimu province. The pharmacognostic study included the determination of macromorphological characteristics, where its weight was determined: 60.38 g and dimensions: width (4.3 cm ± 0.3769), and length: (5.9 cm ± 0.4912); the physicochemical parameters of quality control: foreign matters (0.78%), residual moisture (9.22%), total ash (1.05% ± 0.0816), water-soluble ash (0.49% ± 0.0948) and ash insoluble in acid (0.16% ± 0.0242) and water soluble substances: (6.16% ± 0.7949), ethanol of 50° GL: (5.28% ± 0.2231), ethanol of 70° GL (7.44% ± 0.1271) and ethanol of 96° GL: (7.21% ± 0.0659); which are within the ranges allowe...