Introduction: Adverse Drug Reactions (ADRs) are unwanted clinical or laboratory manifestations that are related to drug use. ADRs are common and are associated with significant risk of morbidity, mortality and hospital admissions. Antipsychotics have a reduced therapeutic window, and have been related to the manifestation of a variety of ADRs. Objective: To evaluate the pattern of ADRs due to antipsychotic drugs detected in patients treated at the Ramón de la Fuente Muñiz National Institute of Psychiatry between December 2021 and May 2022. Methods: Observational, descriptive, prospective and cross-sectional study of a series of cases. The seriousness, severity, and quality of the information in the notification of the ADRs were defined in accordance with “NOM-220-SSA1-2016, Installation and Operation of Pharmacovigilance”, while causality was determined using the Naranjo algorithm....