Cancer is the process of uncontrolled growth and spread of cells in the body, and it can be located anywhere in the body. Every year the cases increase. Among the most frequent types of cancer in women, we have the cervix and breast. For the treatment of breast cancer, the stage of the disease must be taken into account. Trastuzumab is one of the drugs of choice for targeted therapy treatment in breast cancer, it tests positive when cancer cells have high levels of a protein called human epidermal growth factor receptor 2 (HER2). Trastuzumab binds to the HER2 protein and blocks the receptor. This prevents cells from dividing and growing abnormally. The report evaluated the optimization of the use of Trastuzumab 440mg in the Hospital de Alta Complexidad "Virgen de la Puerta" (HACVP), in the months of February-December 2017. Data on the consumption and return of Trastuzumab 440mg were take...

In the present investigation, the effect of oxytocin on lipoperoxidation induced by hyperalgesia in Rattus rattus var. Holtzman ovariectomized. Twenty-four ovariectomized female specimens were used between 2 and 4 months of age, with weights ranging from 200 to 250g, distributed randomly in 4 experimental groups; Control, problem 1, problem 2 and pattern. The control group received distilled water of 0.1mL / 100g, groups 1 and 2 were given oxytocin at a dose of 20IU/kg and 40IU/kg respectively, and finally the tramadol group received doses of 20mg /kg Intraperitoneal route; Followed by hyperalgesia by means of the Hot-plate, a model to evaluate antinociceptive effects against an acute thermal stimulus. The serum samples were extracted and the serum samples were used to determine the antioxidant effect according to levels of malondialdehyde using the colorimetric method of Thiobarbituric ...