The adnexal mass is the tumor that can be located in the ovary, fallopian tube or the surrounding connective tissue (mesosalpinx, mesoovarian tissue and broad ligament). It is a common gynecological problem. The previous determination of benignancy or malignancy is essential for an adequate management. There is a variety of radiological methods, biomarkers and pre-surgical clinical methods and predictive models that have been studied and validated in the world to differentiate the etiology of the adnexal masses. J Kaijser et al performed a systematic review and meta-analysis on the use of predictive mathematical models in the presurgical diagnosis of adnexal masses. At present, the review of the different studies and systematic reviews show that both IOTA LR2 and Simple Rules are the best diagnostic methods available to differentiate benign and malignant adnexal masses preoperatively. In...