Every natural resource required as a therapeutic agent, requires in principle to demonstrate its safety, so determining its acute toxicity is the preliminary step before verifying its efficacy. Objective: To determine the acute toxic potential of the ethanolic extract of Campsiandra angustifolia Spruce Ex Benth (huacapurana). Methodology: Descriptive toxicological study and experimental design, which assessed clinical, biochemical and anatomical parameters in albino mice Balb / C strain. Results: The DMSO group had on average a weight differential between day 0 and the 14th day of 5.24 g (SD of 1.757), in the experimental groups weight loss predominated between 2.06 to 4.41 g) and toxicity measured by the death parameter was 60% for the root extract at 25 mg / kg and for the leaves it was 40% for the bark and leaves at a dose of 200 mg / kg; The observed microscopic variables were accomp...