Objectives. To characterize the evolution of post-COVID-19 syndrome in Cochabamba-Bolivia, 2020-2021. Methods. Prospective, observational and analytical study. The sample consisted of 62 patients surveyed with COVID-19. Symptom severity and persistence were investigated. Fisher's exact test, calculation of the n coefficient, Kruskal-Wallis test, Mann-Whitney U, in addition to binary logistic regression were applied. Results. The mean age was 34.2 ± 11.6 years; dyspnea was present in 45% and cough with 42%; precordial pain with 30%; asthenia and myalgias with 29%; anxiety and depression with 47%, memory and concentration alteration with 24%; predominant risk factor obesity in 11%. Symptom evolution was for more than 10 days in 48%; hospitalization was between 1 to 7 days in 23 % of cases; a decrease in work performance was observedin 34%, in quality of life in 23% and economic affectat...