The crisis in Venezuela has led a large number of citizens to migrate to different countries, including Peru; however, this has brought with it a series of challenges in terms of physical and mental health for Venezuelan migrants. Given this situation, the present research aims to examine the relationship between acculturative stress, health-related quality of life and sociodemographic variables such as age, sex, type and hours of work, as well as having legal documents in force. A non-experimental and cross-sectional study was carried out, the sample was composed of 608 Venezuelan migrants, who were selected through a non-probabilistic snowball sampling. The results obtained showed significant relationships between acculturative stress and health-related quality of life (physical and mental health). Similarly, older immigrants who have legal documents, work longer hours, and have inform...