Background Takotsubo syndrome (TTS) is characterized by acute, transient systolic dysfunction of the left ventricle not attributed to coronary artery disease (CAD). Hypothesis There are differences in hospital outcomes in patients admitted with TTS based on their gender. Methods The National Inpatient Sample database was searched for patients admitted with a principal diagnosis of TTS from 2006 to 2014 using the ICD9‐CM code 429.83. Using Pearson's χ 2 and Student's t test analyses, the P ‐value was calculated for differences among baseline characteristics of patients. Multivariate regression models were then created to adjust for potential confounders. Results A total of 39 662 admissions with TTS were identified, 91.7% female and 8.3% male with mean age of 66.5 and 61.6 years, respectively. The incidence of TTS increased progressively from 2006 to 2014. Female patients were more l...