The psychological well-being (PW) is a quality of life indicator at individual and collective levels. The university population is vulnerable to low levels of PW. Sex and personality features affect the PW. To deepen one’s knowledge of these factors would be of value to the development of interventions – according to the specific requirements for college students. The objective of this paper is to compare the predictive capacity of sex and personality features on the dimensions of the PW, and analyze if sex has a moderating effect in relation to personality and PW. We evaluated to 407 college students through self-report questionnaires. Sex resulted a significant predictor for autonomy and personal growth. The personality features showed predictive capacity over the dimensions of PW: extraversion, neuroticism, self-acceptance awareness, and control of the environment; extraversion an...