Introduction Special histologic subtypes of breast cancer have a unique biological behavior and outcomes. The literature has demonstrated that histologic and phenotype subclassification of breast cancer varies according to race and populations. Our aim was to describe the clinicopathological characteristics and outcomes of breast cancer with special histological subtypes in a Latin/Hispanic population. Methods A retrospective study was conducted. We reviewed the medical records of patients newly diagnosed with special histological subtypes of breast cancer at a single tertiary reference cancer center in Peru from 2014 to 2019. Results A total of 479 patients were included, the median age at diagnosis was 55 years (range 26–89). The majority of patients were from a metropolitan area (59.1%). The most common histological subtype was lobular (34.9%), followed by mucinous (12.7%), papillar...