The aim of this clinical report case was to perform non-instrumental pulp therapy with CTZ in temporary dental organs in a patient with sickle cell disease (SCD). Female 5 years 7 months old, diagnosed with SCD was treated at Regional Hospital of High Speciality of the Child “Dr. Rodolfo Nieto Padrón” in the pediatric dentistry area. At the clinical observation presented tendons and conjunctival palidity, at the intraoral level presented mucous pallidity, hypomineralization, caries in various dental organs (DO), the results of blood biometry were a hemoglobin: 6.04 g/dl, erythrocytes: 1.82 g/ dl, leukocytes : 15 450 x 103/µL. Dental diagnosis was early childhood caries and pulpar necrosis in temporary molars 64 and 85 the first with dentoalveolar abscess. Non-instrumental pulp therapy treatment was carried out with CTZ in both temporary molars with pulp necrosis and as temporary gl...