Peroral modified drug delivery systems on the market release fue drug by either 0-order, 1º-order, square root oftime or mixed rate. This means that the drugis released mto the gastrointestinallumenin amounts being either constantper unit of time or decreasingwith time. However, physiologically absorption from the GI lumen gets slower and more difficult past the small intestme. A novel drug delivery system is described far 24 horus drug delivery which follows approximate 0-orden release throughout the small intestine, but releases increasing amounts of drug once in the colon ta compensate for increasingly more difficult absorption. Nearly constant steady state drug plasma concentrations are achieved . The novel drug delivery system is a two layered dosage form with an immediate release layer and a modified release layer. The latter ene is a hydrogel piston pump comprised of a drug core ...

Exposure of the human body to high altitude (H) results in significant physiologic changes and may precipitate mountain sickness, ranging from mild symptoms above 2500 m to severe symptoms above 4000 m, and coma a teven higher altitude. In a previous study in our labs we found et vivo an increase in meperidine (M) upteke wilh increase in number of erythrocytes (RBG). One of the major physiologic changes at H is a increase in hematocrit and RBC. The study was carried out in three groups of healthy volunteers (18-2' y): at sea level (L), at 4360 m the day after arrival at H (HA), and at 4360 m in subjects residing > 10 mo at H (HC), 0.75 mglkg of M was administered I.M. between 8-9 a.m. Blood was collected for 12 h. M was measured in whole blood (WB), plasma (P) and plasma -water (PW). The pharmacokinetic parameters derived from curve-fitting were analyzed by ANOVA. Significant changes ...

Entre las muchas profesiones, las profesiones de salud -a saber, los profesionales médicos y farmacéuticos, académicos e investigadores- parecen tener una posición única: por un lado, están cerca a las ciencias naturales; por otro lado, sirven el cuerpo y la mente de su prójimo. Idealmente, este servicio es dado principalmente no con el propósito de satisfacción propia, sino más bien con el interés de ayudar a la humanidad.

Exposure of the human body to high altitude (H) results in significant physiologic changes and may precipitate mountain sickness, ranging from mild symptoms above 2500 m to severe symptoms above 4000 m, and coma a teven higher altitude. In a previous study in our labs we found et vivo an increase in meperidine (M) upteke wilh increase in number of erythrocytes (RBG). One of the major physiologic changes at H is a increase in hematocrit and RBC. The study was carried out in three groups of healthy volunteers (18-2' y): at sea level (L), at 4360 m the day after arrival at H (HA), and at 4360 m in subjects residing > 10 mo at H (HC), 0.75 mglkg of M was administered I.M. between 8-9 a.m. Blood was collected for 12 h. M was measured in whole blood (WB), plasma (P) and plasma -water (PW). The pharmacokinetic parameters derived from curve-fitting were analyzed by ANOVA. Significant changes ...

Entre las muchas profesiones, las profesiones de salud -a saber, los profesionales médicos y farmacéuticos, académicos e investigadores- parecen tener una posición única: por un lado, están cerca a las ciencias naturales; por otro lado, sirven el cuerpo y la mente de su prójimo. Idealmente, este servicio es dado principalmente no con el propósito de satisfacción propia, sino más bien con el interés de ayudar a la humanidad.

Peroral modified drug delivery systems on the market release fue drug by either 0-order, 1º-order, square root oftime or mixed rate. This means that the drugis released mto the gastrointestinallumenin amounts being either constantper unit of time or decreasingwith time. However, physiologically absorption from the GI lumen gets slower and more difficult past the small intestme. A novel drug delivery system is described far 24 horus drug delivery which follows approximate 0-orden release throughout the small intestine, but releases increasing amounts of drug once in the colon ta compensate for increasingly more difficult absorption. Nearly constant steady state drug plasma concentrations are achieved . The novel drug delivery system is a two layered dosage form with an immediate release layer and a modified release layer. The latter ene is a hydrogel piston pump comprised of a drug core ...